Alzheimer’s disease (AD) is the most common form of progressively disabling degenerative dementia. In dementia in general, there are, unfortunately, even from earliest stages disease, associated behavioural and psychological symptoms (BPSD), more pronouncedly AD, addition to cognitive impairment. There are no specific drugs for treatment BPSDs. Therefore, remains an unmet medical need. To date,...

A 29-year-old male presented to Aga Khan University Hospital with complaints of fever, body-aches, vomiting and one episode gum bleeding. Dengue antigen test done prior presentation was positive. He admitted for medical management. During hospital stay, the patient developed manic symptoms including over-talkativeness, expansive mood, disinhibited behavior, excessive planning, paranoia aggressi...

BACKGROUND In 2012, an Indian parliamentary committee reported that manufacturing licenses for large numbers of fixed dose combination (FDC) drugs had been issued by state authorities without prior approval of the Central Drugs Standard Control Organization (CDSCO) in violation of rules, and considered that some ambiguity until 1 May 2002 about states' powers might have contributed. To our know...

Priapism, a rare but well-known adverse reaction of first and second generation anti-psychotics, has been hypothesized to be associated with blockade of alpha 1 receptors. However, genetic abnormalities or heritability of affected cytochrome P450 alleles has not been ruled out as a causal mechanism. A case is presented with three episodes of priapism within 17 days while taking standard FDA (Fo...

A 32-year-old female with depression on treatment, was presented with acute psychosis, behavioural symptoms, autonomic instability and a prodromal illness. This occurred on a background of a strong family history of schizophrenia. Despite escalating doses of anti-psychotics, she failed to improve. Her CSF showed a lymphocytic pleocytosis and confirmed the presence of anti-NMDAR antibodies. Foll...

The psychiatric patient care facilities and services of fifty seven general hospitals attached to medical colleges in India were studied based on data pertaining to 1988. The average bed strength was 25 beds while the average length of stay was 21 days. Functional psychotics formed 62% of the discharged patients. On the average, 2914 new psychiatric outpatients were registered per hospital and ...

A 35 yrs, old male, a known case of Paranoid Schizophrenia for last 20 yrs, not respond to conventional anti-psychotics and was prescribed Olanzapine upto to 30mg/day. Patient developed manic symptoms during olanzapine therapy. He also showed a strong desire or sense of compu'sion to take the substance and progressive neglect of alternative pleasurable activities and fulfilled the criteria for ...