Although electrocardiographic evidence of right ventricular hypertrophy is considered common in newborn infants with coarctation of the aorta, the reason for this finding is not well established. Investigations of the pulmonary vascular bed of these infants have resulted in variable findings, probably due to the differences in morphometric techniques, coexisting cardiac defects, and variable po...

Primary sarcomas of the major blood vessels can be classified based on location in relationship to the wall or by histologic type. Angiosarcomas are malignant neoplasms that arise from the endothelial lining of the blood vessels; those arising in the intimal compartment of pulmonary artery are rare. We report a case of pulmonary artery angiosarcoma in a 36-year old female with pulmonary masses....

Exposure of native sea level dwellers to chronic hypoxia due to migration to high altitude leads to the development of increased pulmonary vascular resistance causing pulmonary hypertension. In some susceptible individuals this progressively worsens causing right ventricular failure and ultimately death. The increased pulmonary vascular resistance has previously been attributed to two structura...

introduction:adenosine as a potent vasodilator has physiological role in regulation of regional cerebral blood flow (rcbf). metod: laser-dِoppler flowmetry technique was used to study pial vessels blood flow responses to adenosine receptors agonists and antagonist. male sprague dawley rats (250-350g) that were housed in standard conditions, were anesthetized with urethane (1.5g/kg). adenosine (g...

Congenital tricuspid atresia has been classified into two groups, those with and those without transposition of the great vessels (Kiihne, 1906). Each of these groups is further subdivided according to whether there is an increase or a decrease in the pulmonary blood flow (Edwards and Burchell, 1949). Tricuspid atresia with transposition of the great vessels and an increase in pulmonary blood f...

The study of pulmonary vessels has assumed great importance in the last decade since the advent of corrective surgery for congenital cardiac defects. Several papers have been written on the structure and state of these vessels, in utero, in neonatal life and during later years (Edwards, 1957; Civin and Edwards, 1951; Dammann and Ferencz, 1956a). These papers stress the basic differences in the ...

Rho-kinase-mediated vasoconstriction and endothelial dysfunction are considered two primary instigators of pulmonary arterial hypertension (PAH). However, their contribution to the adverse changes in pulmonary blood flow distribution associated with PAH has not been addressed. This study utilizes synchrotron radiation microangiography to assess the specific role, and contribution of, Rho-kinase...

THE EFFECTS of breathing low oxygen (acute hypoxia) on the pulmonary cireulation in normal subjects and in patients with various cardiopulmonary diseases have been reported by many workers.'-8 In general, during the period of acute hypoxia the pulmonary arterial pressure and the pulmonary blood flow usually rise, while the pulmonary wedge or left atrial pressure is unchanged or slightly increas...