The aim of the study was to evaluate the effects of a highly potent bisphosphonate, zoledronic acid (ZOL), on cultured odontoblast-like cells MDPC-23. The cells (1.5×10(4)cells/cm(2)) were seeded for 48h in wells of 24-well dished. Then, the plain culture medium (DMEM) was replaced by fresh medium without fetal bovine serum. After 24h, ZOL (1 or 5μM) was added to the medium and maintained in co...

A massive periodontal destruction can affect the root canal (RC) system and potentially expose pulpo-dentinal complex to opportunistic bacteria. Streptococcus mutans is a major pathogen of human caries diseases, its virulence mostly resides in ability adhere collagen form biofilms, due collagen-binding proteins (CBPs) Cnm Cbm. Seventeen patients affected by severe endo-periodontal lesions witho...

The effects of dietary sucrose and systemic glucocorticoid treatment on the response of the pulpodentinal complex to dental caries were examined in an experimental rat model. The possible role of dentinal caries on dentin formation was also examined. After 5-6 weeks of a dietary and/or medication period, the areas of dentin formation and dentinal caries were quantified in the molars of growing ...

Bacterial invasion of dentinal tubules commonly occurs when dentin is exposed following a breach in the integrity of the overlying enamel or cementum. Bacterial products diffuse through the dentinal tubule toward the pulp and evoke inflammatory changes in the pulpo-dentin complex. These may eliminate the bacterial insult and block the route of infection. Unchecked, invasion results in pulpitis ...

The main ways of interrelation pulp and periodontal tissues are normally the apical openings roots teeth additional root canals. In addition, it is important to remember that bulk tooth dentin, permeated with smallest dentine tubules, which can also serve as a road in «endodont-periodontal» system. A doctor who faced endo-periodontal lesion (EPL) faces difficult task, consists competent plannin...

introduction microorganisms have an essential role in pulpo-periapical pathosis, therefore obtaining a successful treatment has a direct relationship with their elimination. according to previous studies, the most reliable method of sterilization is autoclave ,but in some instances there are limitations for using this method, and we need an alternative .one of the most popular and wide-spread m...

Objective: Ishemic bone disease has multifactorial etiologies. Cronic dental infections should be eliminated to prevent osteonecrosis of the jaw. Case report: We report an unusual case of osteonecrosis due to the pulpal-peridontal syndrome and subsequent pulp necrosis. A case of 38 year old woman who presented with exposed bone, 8 mm in diameter, in the lingual area of the right lower third mol...