introduction: pulsed dye laser (pdl) has been used to treat acne lesions and scar erythema by interrupting superficial vasculature. salicylic acid chemical peels are employed chiefly due to their lipophilic, comedolytic, and anti-inflammatory properties. although studies have looked at peels and laser therapy independently in acne management, we examined these treatments in combination. our pri...

INTRODUCTION AND OBJECTIVE Capillary malformations are the most common vascular malformations in childhood. The current treatment of choice is pulsed dye laser (PDL) therapy, but this frequently does not result in complete resolution. The search for alternative treatment strategies thus continues. In this study we describe our experience with the use of sequential dual-wavelength PDL and Nd:YAG...

BACKGROUND Infantile hemangiomas (IH) are common pediatric tumors. This meta-analysis was performed to review the therapeutic efficacy and safety of pulsed dye laser (PDL) in the treatment of IH. METHODS Seven databases were searched, including PubMed, OvidSP, Karger, Elsevier, EMBASE, Web of Science and Wiley Online Library. The review collected the characteristics of year of publication, he...

R ecent data show that melasma lesions have, in addition to increased pigmentation, more elastosis and vascularization than perilesional skin. The stabilized formulation of Kligman preparation has shown significant improvements in the treatment of melasma. However, most of the treatments only target the pigmentation, and none of them has been demonstrated so far to prevent the frequent relapses...

Acne rosacea is a relatively common disease, which usually manifests in the third and fourth decades of life. It has an inflammatory condition (Papules and pustules) associated with telangiectasis, erythema and sometimes rhinophyma at the end stage of the disease. Pulsed-dye-laser (PDL), which has been designed for treatment of vascular lesions, may be used in treatment of acne rosacea. We pres...

BACKGROUND Pulsed dye laser (PDL) is a commonly utilized treatment for port wine stain birthmarks (PWS) in the United States; however, results are variable and few patients achieve complete removal. Photodynamic therapy (PDT) is commonly used in China, but treatment associated photosensitivity lasts several weeks and scarring may occur. We propose an alternative treatment option, combined PDT+P...

BACKGROUND AND OBJECTIVE Pulsed dye laser (PDL) treatment of cutaneous vascular lesions is associated with variable and unpredictable efficacy. Thus, alternative treatment modalities are needed. Previous in vitro and in vivo studies have demonstrated enhanced selective vascular destruction with benzoporphyrin derivative (BPD) monoacid ring A photodynamic therapy (PDT) followed immediately by PD...

BACKGROUND AND OBJECTIVES Previous in vitro studies demonstrated the potential utility of benzoporphyrin derivative monoacid ring A (BPD) photodynamic therapy (PDT) for vascular destruction. Moreover, the effects of PDT were enhanced when this intervention was followed immediately by pulsed dye laser (PDL) irradiation (PDT/PDL). We further evaluate vascular effects of PDT alone, PDL alone and P...

BACKGROUND Administration of topical rapamycin (RPM) suppresses the regeneration and revascularization of photocoagulated blood vessels induced by pulsed dye laser (PDL). OBJECTIVE To systematically elucidate the molecular pathophysiology of the inhibition of PDL-induced angiogenesis by topical RPM in a rodent model. METHODS The mRNA expression profiles of 86 angiogenic genes and phosphoryl...