BACKGROUND Multimodality biological response-modifier therapy that includes photopheresis, interferon, and bexarotene is the standard of care in our institution for advanced cutaneous T-cell lymphoma with peripheral blood involvement. We added psoralen plus long-wave UV-A (PUVA) to this regimen in 5 patients with Sézary syndrome. OBSERVATIONS All patients responded with decreased Sézary count...

INTRODUCTION The use of psoralen baths with long-wave UV radiation, known as PUVA bath therapy, is useful in the treatment of psoriasis. The therapy is not associated with systemic adverse effects and the dose of UV-A radiation administered is lower. The objectives of this study aimed to identify the variables that influence the effectiveness of PUVA bath therapy and the duration of remission, ...

BACKGROUND Alopecia areata (AA) is believed to be an organ-specific autoimmune disease in which a mononuclear cell infiltrate develops in and around anagen hair follicles. There is no definitive therapy for AA. OBJECTIVE We sought to determine whether the combination therapy of cyclosporine and psoralen plus ultraviolet A (PUVA) could be an effective treatment for severe AA. METHODS A total...

BACKGROUND/METHODS The treatment of psoriasis with high-dose exposure to oral psoralen and ultraviolet-A light (i.e., PUVA) substantially increases the risk of cutaneous squamous cell cancer, but not of basal cell cancer, within a decade of beginning treatment. To assess the persistence of cancer risk among individuals treated with PUVA, including those who discontinued therapy long ago and tho...

BACKGROUND Psoralen ultraviolet A (PUVA) is a widely used first-line therapy for treatment of early cutaneous T-cell lymphoma. Narrow band UVB (UVB-NB) (311 nm) has been recently introduced as another effective line of treatment. It is postulated that the efficacy of UVB-NB could be enhanced by addition of psoralen. AIM The aim of the present work was to compare the clinical and histopatholog...

The choice of tactics for managing a patient with mycosis fungoides is determined by the stage disease. In early stages fungoides, treatment approach using external therapy and various ultraviolet irradiation spectra (UVB-311 nm PUVA therapy) preferable. With insufficient efficiency / or short remissions in some patients, it possible to use combined methods stages: UVB-311 therapy. combination ...

Abstract Severe chronic hand eczema resistant to topical corticosteroid treatment is an important cause of morbidity and occupational disability. There uncertainty regarding the best approach currently no pathway generally accepted by UK dermatologists. The primary aim ALPHA trial was compare alitretinoin immersion psoralen plus ultraviolet A (PUVA) as a first-line therapy in terms disease acti...

Case Report A 53-year-old male anaesthetist with a widespread, histologically proven psoriasis vulgaris was treated with oral photochemotherapy (PUVA) after failure of multiple intensive topical treatments and poor response to UVA-UVB phototherapy. PUVA was begun according to our standard protocol: 2 h after oral administration of 5-MOP 100 mg (Geralen , 1.2 mg/kg body weight), the patient was ...

Case Report A 53-year-old male anaesthetist with a widespread, histologically proven psoriasis vulgaris was treated with oral photochemotherapy (PUVA) after failure of multiple intensive topical treatments and poor response to UVA-UVB phototherapy. PUVA was begun according to our standard protocol: 2 h after oral administration of 5-MOP 100 mg (Geralen , 1.2 mg/kg body weight), the patient was ...