Opening of the permeability transition (PT) pore is a central feature of apoptosis induction by chemical stress. One component of the PT pore, the mitochondrial benzodiazepine receptor (mBzR), has recently received attention for its potential role in modulating PT pore function. Specifically, antagonistic ligands of the mBzR, such as 1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinoline...

the effects of three doses of spirodiclofen sc 240 in comparison with three registered ‎acaricides on citrus rust mite in western part of mazandaran province during period of 2003-‎‎2004 studied. the bcr design was used to assign four replications of seven treatments ‎‎(spirodiclofen sc 240 at doses 0.1, 0.18 and 0.27 millilitre in 1000cc water, fenproximate, ‎pyridaben, abamectin) including an...

Modern determination techniques for pesticides must yield identification quickly with high confidence for timely enforcement of tolerances. A protocol for the collection of liquid chromatography (LC) electrospray ionization (ESI)-quadruple linear ion trap (Q-LIT) mass spectrometry (MS) library spectra was developed. Following the protocol, an enhanced product ion (EPI) library of 240 pesticides...

Background—Positron-emission tomography (PET) tracers for myocardial perfusion are commonly labeled with short-lived isotopes that limit their widespread clinical use. F-BMS-747158-02 (F-BMS) is a novel pyridaben derivative that was evaluated for assessment of myocardial perfusion by comparison with N-ammonia (NH3) and with radioactive microspheres in a pig model. Methods and Results—Fourteen p...

Parkinson's disease (PD) is a neurodegenerative disease in which the etiology of 90 percent of the patients is unknown. Pesticide exposure is a major risk factor for PD, and paraquat (PQ), pyridaben (PY) and maneb (MN) are amongst the most widely used pesticides. We studied mRNA expression using transcriptome sequencing (RNA-Seq) in the ventral midbrain (VMB) and striatum (STR) of PQ, PY and pa...

Flowers are frequently treated with pesticides and, as a result, florists handling daily a large number of flowers can be exposed to pesticide residues. A study was conducted among twenty volunteer florists located in Namur Province and in the Brussels Capital Region of Belgium in order to assess their potential dermal exposure to dislodgeable pesticide residues transferred from flowers to hand...

In this issue of Circulation Research, Cherednichenko et al1 describe an NADH oxidase activity that regulates the ryanodine receptor ion channel (RyR2) in cardiac muscle. Mammalian tissues express three closely related 560-kDa ryanodine receptors (RyRs) encoded by separate genes. RyR1 is the predominant isoform in skeletal muscle, and RyR2 predominates in heart. RyR3 is widely expressed at low ...