Two series of novel derivatives of pyridine-2,6-dicarboxylic acid with potential as polydentate ligands were synthesized from pyridine-2,6-dicarboxylic acid. All new compounds were characterized by NMR, MS, IR, and EA.
Silicon containing pyridine and quinoline sulfides have been prepared using phase transfer catalytic system thiol/alkyl halide / solid KOH/18-crown-6 / toluene. The target S-ethers were isolated in yields up to 81%. The cytotoxicity of the synthesized compounds was studied. Among pyridine sulfides S-[3-(1-methyl- 1-silacyclohexyl)propyl] derivatives 5e and 6e exhibit the highest cytotoxicity. A...
