Pyridostigmine bromide is a carbamate AChE inhibitor with a positively charged “quaternary ammonium” group, which is believed to prevent its penetration through the “blood-brain barrier,” a layer of cells that controls which substances may penetrate from the general circulation into the brain. Therefore, side effects of PB are typically those of heightened peripheral cholinergic activity (nicot...

A 42-year-old male presented with an 8-month history of a thymic tumor associated with myasthenia gravis (MG) (Figure 1). The clinical stage was IIa according to the Myasthenia Gravis Foundation of America (MGFA), an electromyography (EMG) study was abnormal, and serum acetylcholine receptor (AChR) antibody testing was positive. The patient’s clinical state was stable on pyridostigmine bromide,...

Background: Treatment of chronic constipation is creating one of the major problems for doctors and patients. Pyridostigmine increases the gastrointestinal motility through the effects on cholinesterase. It seems that this mechanism can reduce chronic constipation. The aim of this study was to compare the effects of pyridostigmine and bisacodyl on chronic constipation. Methods: This study wa...

Myasthenia Gravis (MG) is an autoimmune disease that affects neuromuscular junctions and characterized by muscle weakness as a result of autoantibodies against certain proteins. As heterogeneous disorder, MG presents with different types, including neonatal, ocular generalized in both juveniles adults. Different types antibodies serve role how presents. The main biological characteristic the pr...

Four healthy males exercised in two experiments at ambient temperatures of 22, 29, and 36 degrees C with the relative humidity at 30% in all environments (Tdp = 3.9, 9.9, and 15.8 degrees C). One experiment in each environment was done 150 min after 30 mg oral pyridostigmine bromide (PYR) administration, and the second experiment was done on a separate day with no medication (CON). Red blood ce...

Many Persian Gulf War veterans took pyridostigmine bromide (PB) during the Persian Gulf War. Previous research suggests that PB intake and insecticide exposure may reduce muscular strength. During 1994 and 1995, we examined the relationships between self-reported PB intake, self-reported exposures, and handgrip strength among 527 Gulf War veterans (GWVs) and 969 nondeployed veterans of that era...

I read the recent publication by Leong et al on the effect of pyridostigmine or Mestinon on human platelet aggregation with a great interest. In medicine, pyridostigmine has been investigated for its effect on biochemical and hematological parameters. Indeed, such effects have already been studied in animal models. Somani et al reported on signifi cant change due to receipt of pyridostigmine in...