The water-soluble vitamin B6 (pyridoxine) is important for normal cellular functions, growth, and development. The vitamin is obtained from two exogenous sources: a dietary source, which is absorbed in the small intestine, and a bacterial source, where the vitamin is synthesized in significant quantities by the normal microflora of the large intestine. Evidence exists to suggest the bioavailabi...

1. The nucleic acid metabolism in the pyridoxine-deficient rat has been investigated through studies on the incorporation ofradioactivity from various isotopically labelled compounds into liver and spleen DNA and RNA. 2. In pyridoxine deficiency, the incorporation ofradioactivity from sodium [14C]formate was apparently increased. The magnitude of this effect on incorporation into liver RNA and ...

Pyridoxine is used as a supplement for treating conditions such as vitamin deficiency as well as neurological disorders such as depression, epilepsy and autism. A significant neurologic complication of pyridoxine therapy is peripheral neuropathy thought to be a result of long-term and high dose usage. Although pyridoxine-induced neuropathy is transient and can remit after its withdrawal, the pr...

Pyridoxine-dependent epilepsy presents early in life, even in utero. It is usually refractory to conventional antiepileptic medications and responds only to lifelong pyridoxine supplementation. Seizures are usually generalized tonic clonic. We report a 3-year-old child that was born prematurely at 25 weeks of gestation. He presented with abnormal movements in the second month of life. At 10 mon...

A KELATIOXSHIP between pyridoxine deficiency and arteriosclerosis was first suggested by the observation of Rinehart and Greenberg that monkeys fed a diet deficient in pyridoxine developed vascular lesions resembling in many respects those of naturally occurring arteriosclerosis in human beings. Little is known of the precise physiologic role of pyridoxine in human nutrition except that it has ...

By ALFRED GELLHORN, M.D., AND LOGAN 0. JONES, M.D. E VIDENCE from animal experimentation indicates that pyridoxine, a cornponent of the vitamin B complex, is an essential factor for the maintenance and function of hematopoietic tissue. Severe anemia has been induced in dogs’ and swine2 on a pyridoxine deficient diet and the integrity of lymphoid tissue in rats has also been demonstrated to be d...

The absorption of pyridoxine from the intestine of the mouse was studied in whole animals. [3H]Pyridoxine was orally administered and the distribution of isotope between the six recognized forms of vitamin B6 was determined in portal and peripheral blood after the administration. When small doses (1.4 or 14 nmol) were administered, labeled pyridoxine could hardly be found in the portal blood as...

Normobaric supplemental oxygen can prolong seizures not caused by hyperbaric oxygen therapy. In addition, hyperbaric oxygen therapy can cause seizures. The mechanism of hyperbaric oxygen-induced seizures is unknown. We hypothesized that pretreatment with pyridoxine may delay the onset of hyperbaric oxygen-induced seizures, recognizing that pyridoxine is already an antidote for some epileptogeni...

α-Amino adipic semialdehyde (α-AASA) accumulates in body fluids from patients with pyridoxine-dependent epilepsy because of mutations in antiquitin (ALDH7A1) and serves as the biomarker for this condition. We have recently found that the urinary excretion of α-AASA was also increased in molybdenum cofactor and sulfite oxidase deficiencies. The seizures in pyridoxine-dependent epilepsy are cause...

By HENRY FOY AND ATHENA KONDI p YRIDOXINE. Deficiency of pyridoxine (vitamin B11) has been shown to produce an anemia in dogs, rats, pigs, monkeys, chicks and ducks.1’#{176} Poikilocytosis in cattle has been successfully treated with pyridoxine.1#{176} Ramalingaswami and Sinclair1 I have shown that the hematologic abnormality in pyridoxine-deficient rats is a microcytosis, but it is not necessa...