The present experiment was carried out to study the endogenous losses of purine and pyrimidine derivatives from pregnant sows. Three pregnant and three non-pregnant Large White x Landrace sows were fed on a purine-free diet composed of starch, glucose, sucrose and vegetable oil, with casein as the protein source. The experiment began, for the six animals, after diagnosis of pregnancy and was di...

BACKGROUND A series of 6-(substituted aldehyde)-3,4-dihydro-1-(tetrahydro-3,4-dihydroxy-5-(hydroxymethyl) furan-2-yl)-4-phenylpyrimidine-2(1H)-one derivative (6A-6P) was synthesized from the 6-(substituted aldehyde)-4-phenylpyrimidine-2(1H)-one derivative (5A-5P) through following reaction mechanisms Claisen-Schmidt, Cyclization, and Satos fusion. The structures of the synthesized compounds wer...

A series of investigations using mutants of the fungus Neurospora has provided ample evidence that the pyrimidine orotic acid has a significant role in the biological synthesis of the ribose nucleosides uridine and cyti-dine.'-4 By use of isotopically labeled orotic acid several investigators5-8 have recently demonstrated that a similar conclusion may be drawn concerning a function of this pyri...

C-5 alkynylated and N-1 alkylated pyrimidine derivatives were synthesized by N-alkylation reaction of 5-iodouracil in the presence of NaH, as a base, followed by Pd-catalyzed Sonogashira cross-coupling reaction of N-alkyl-5-iodouracil derivatives (1 and 2) with corresponding terminal alkynes. Intramolecular in situ O-heteroannulation ring closure of N-1-alkyl-C-5-alkynylpyrimidine derivatives (...

BARBITURIC acid was first synthesized by Conrad and Guthzeit in 1882, and in 1903 the 5:5-diethyl derivative was introduced into medicine as a hypnotic by Carl Fischer and von Mering, under the name of Veronal. In the past, barbituric acid was usually regarded as the cyclic ureide of malonic acid, i.e. as malonyl urea, and its structural formula written in a form which emphasized this relations...

Chalcone-derived pyrimidine is a well-known heterocyclic compound that commonly present in ribonucleic acid (RNA) and deoxyribonucleic (DNA) bio-isosteres. Pyrimidine derivatives are effective both the electronic industry drug industries. This review highlights synthesis of pyrimidines, namely mono-pyrimidine, bis-pyrimidine, fused pyrimidine, symmetric, asymmetric via one-pot two-pot methods. ...

Introduction: Ligands of adenosine A1Rs are potential candidates for the development drugs treatment paroxysmal supraventricular tachycardia, angina pectoris, hypertriglyceridemia, type 2 diabetes mellitus, neuropathic pain, and heart failure. At same time, there is a deficiency that can regulate functions A1 receptors. A number A1-antagonists at various stages clinical trials; other not very s...