Although the interval mapping method is widely used for mapping quantitative trait loci (QTLs), it is not very well suited for mapping multiple QTLs. Here, we present the results of a computer simulation to study the application of exact and approximate models for multiple QTLs. In particular, we focus on an automatic two-stage procedure in which in the first stage “important” markers are selec...

Some diseases, such as cystic fibrosis and Huntington’s disease, are the result of a change in a single gene. No single gene is responsible for alcohol abuse and dependence, however. Many genes that play roles in a variety of normal human behaviors and sensory perception are involved. Research has not yet pinpointed specific genes that “predispose” a person to alcohol abuse or dependence. Once ...

Alcoholism is a quantitative disorder that is caused by the combined influences of numerous genes (i.e., quantitative trait loci [QTLs]) and environmental factors. To identify QTLs for alcoholism, researchers compare subject groups (e.g., inbred mouse strains) that differ in both their genetic makeup (i.e., genotype) and alcohol-related trait (e.g., sensitivity to certain alcohol effects). Usin...

With the increasing number of polymorphic markers identified on the genetic map, positional cloning has become an extremely powerful tool, permitting the linkage and identification of a large number of disease genes. As the human genome project pro­ gresses and the gene map becomes as dense as the microsatellite polymorphism map, scientists will identify more disease genes through a combination...

pod length is one of the effective components on canola yield selection on the basis of which can increase not only the seed yield but also the oil yield. molecular markers asso-ciated with long pod loci were identified in a doubled haploid population derived from a cross between the canola lines ‘quantum’ (long pod) ‘china a’ (short pod) using rapd and bulked segregant analysis. a molecular ma...

During the last 30 years, the cattle genome map has been expanded from 4 genes linked on chromosome X to over 22,000 genes identified in the cattle genome sequence assembly. This progress has been achieved due to numerous projects on linkage and physical mapping of the cattle genome driven by its agricultural and scientific significance. Indeed, the high-resolution mapping and functional analys...

During the last 30 years, the cattle genome map has been expanded from 4 genes linked on chromosome X to over 22,000 genes identified in the cattle genome sequence assembly. This progress has been achieved due to numerous projects on linkage and physical mapping of the cattle genome driven by its agricultural and scientific significance. Indeed, the high-resolution mapping and functional analys...