the lack of variation in antifungal drugs, and the misuse or inappropriate use usually causes resistant strains of the yeast in human’s normal flora. unfortunately, a large number of candida infection cases in immunosuppressed patients with insufficient treatment eventually can cause patient's death. the aim of this study was to evaluate the in vitro conventional antifungal azole compounds with...

We consider a second-order conservative nonlinear numerical scheme for the Ncomponent Cahn–Hilliard system modeling the phase separation of a N-component mixture. The scheme is based on a Crank–Nicolson finite-difference method and is solved by an efficient and accurate nonlinear multigrid method. We numerically demonstrate the second-order accuracy of the numerical scheme. We observe that our ...

A convenient synthetic method for the marine antibiotic (-)-malyngolide and its stereoisomers was accomplished from a chiral alpha-alkoxyketone (4), which was readily available as a chiron. Chiral quaternary carbon synthons (5a) and (5b) as the key intermediates were constructed by the chelation controlled addition of Grignard reagent to 4. The diastereomeric mixture of 5a and 5b was readily tr...

10.1586/14750708.3.2.215 © 2 Antimuscarinic drugs currently form the mainstay of pharmacotherapy for overactive bladder. Trospium chloride, an antimuscarinic with an unusual quaternary amine structure, has recently gained approval in the USA for the treatment of this condition. As a quaternary amine, trospium has pharmacological properties that are distinct from other available antimuscarinics ...