Liver diseases associated with its function in detoxification of xenobiotics are one of the most common causes of death. Side effects of drugs treating liver diseases have marred their popularity. This work was therefore designed to investigate the ameliorating effect of ethanolic leaves extract of phyllantus amarus on carbon tetrachloride (CCl4) induced hepatotocity in albino rats. Thirty six ...

This study investigated the toxicity of sodium fluoride on male reproductive hormones and ameliorative effects extract Phyllantus amarus adult albino rats. The consisted six equal groups five rats that were administered with over a period two weeks. result indicates possible hormone lipid profile probable capacity to ameliorate this toxicity.

Peripheral blood is an accessible adult stem cell source for both basic and applied research including clinical applications. Peripheral blood mononuclear cells (PBMCs) were reported to possess multipotent progenitor cell populations and has the potential to differentiate into blood cells, endothelial cells, hepatocytes, cardiomyogenic cells, smooth muscle cells, osteoblasts and so on. They can...

The present paper describes enhancement of lignans, phyllanthin and hypophyllanthin present in Phyllanthus amarus plant. Supplementation was done to enhance secondary metabolites by modifying the media and treatment with different growth promoters and abiotic elicitors to increase the content of hepatoprotective bioactives in immobilized cell cultures, after incubation for 21 days. MS medium wa...

BACKGROUND Pseudomonas aeruginosa infection is a leading cause of morbidity and mortality in burn and immune-compromised patients. In recent studies, researchers have drawn their attention towards ecofriendly synthesis of nanoparticles and their activity against multidrug resistant microbes. In this study, silver nanoparticles were synthesized from aqueous extract of Phyllanthus amarus. The syn...

the present study was aimed at the development of a somoclonal variant and isozyme marker for phyllanthus amarus schum & thonn using inter-nodal segments and the enzyme peroxidase. maximum callus proliferation was obtained on murashige and skoog’s medium supplemented (ms) with 1.0 mg/l of 2,4-dichlorophenoxyacetic acid. three weeks-old pale yellowish white semi-friable callus was used for o...

Seven medicinal plants popularly used for treating malaria in West Africa were selected to assess herb-drug interaction potential through a series of in vitro methods. Fluorescent cytochrome P450 (CYP) assays were conducted using the recombinant CYP enzymes for CYP1A2, CYP2A6, CYP2B6, CYP2C9, CYP2C19, CYP2D6 and CYP3A4 to assess the effect of the methanolic extracts on the metabolic activity of...

Effect of bacteriophages and chamber bitter (Phyllanthus amarus) in combination on Vibrio parahaemolyticus Truong Thi Bich Van, Do Tan Khang, Le Viet Dung, Hoang Bao Ngoc, Nguyen Pham Anh Thi, Tran Thanh Men, Vo Ngoc Tram Anh, Kim Thoa