A simple, precise, accurate and rapid high performance thin layer chromatographic method has been developed for the simultaneous estimation of ondansetron combinations in solid dosage form with omeprazole and rabeprazole, respectively. The method involved separation of components by TLC on a precoated silica gel 60 F(254) using a mixture of dichloromethane:methanol (9:1) as a mobile phase. Dete...

This study aimed to determine the influence of proton pump inhibitors (PPIs) on the pharmacokinetics of voriconazole and to characterise potential drug-drug interactions (DDIs) between voriconazole and various PPIs (omeprazole, esomeprazole, lansoprazole and rabeprazole). Using adjusted physicochemical data and the pharmacokinetic (PK) parameters of voriconazole and PPIs, physiologically based ...

To develop and validate simple, reproducible, stability indicating reverse phase high performance liquid chromatography for the simultaneous determination of Rebeprazole and Diclofenac in pharmaceutical solid dosage form. The method was based on HPLC separation of both drugs in reverse phase mode using Phenomenox C18 column with Waters HPLC system by using mobile phase composition of acetonitri...

OBJECTIVES Controversy has been prompted based on drug interaction between proton pump inhibitors (PPIs) and aspirin/clopidogrel leading to weakened effects. However, whether such interaction was drug-specific or class effect remains controversial. This study predicted the impact of esomeprazole and rabeprazole on efficacy of dual antiplatelet therapy (DAPT). METHODS This study, involving 150...

Background\Aim: Quadruple daily administration of proton-pump inhibitor (PPI) therapy achieves potent acid inhibition, and combined with amoxicillin, with its pharmacodynamic and pharmacokinetic characteristics, may be efficient for Helicobacter pylori eradication. We compared the efficacy of two optimized high-dose dual therapies with a bismuth-containing quadruple regimen for treating H. pylo...

BACKGROUND Scant data exist on the normal range of serum gastrin in infants. In phase I and III trials of rabeprazole in gastroesophageal reflux disease, we studied serum gastrin levels in infants 1 to 11 months old, and assessed normal ranges and the effect of acid-suppressive drugs. METHODS Overall, 349 treatment-naïve or treatment-experienced (previously exposed to proton pump inhibitors a...

Statistical experimental design was used to optimize the chromatographic separations of two pharmaceutical compounds from their respective potential impurities. A fractional factorial design was utilized to study the effects of pH, organic solvent in mobile phases A&B, and flow rate on the resolution of Rabeprazole and Rabeprazole Sulfone, which had closely eluting peaks. A desirability functio...

Currently, peptic ulcer disease remains the most common of digestive system. Ulcerative bleeding is a terrible complication. The main condition for successful conservative treatment gastrointestinal that occurs against background acid-dependent diseases adequate acid-reducing therapy. We conducted study comparing different modes administration proton pump blockers. To this end, three groups wer...

I n t e r v e n t i o n 70 patients each were allocated to 4 treatments: 1) a 10-day course of once-daily levofloxacin, 500 mg; twice-daily amoxicillin, 1 g; twice-daily rabeprazole, 20 mg (LAR); 2) a 10-day course of once-daily levofloxacin, 500 mg; twice-daily tinidazole, 500 mg; and twice-daily rabeprazole, 20 mg (LTR); 3) a 7-day course of 4 times daily tetracycline, 500 mg; 3 times daily m...

Background. The aim of this study was to compare the effect of high-dose oral rabeprazole versus high-dose IV PPI on rebleeding after endoscopic treatment of bleeding peptic ulcers. Methods. This was a two-center, prospective, randomized, controlled trial. Patients with a high-risk bleeding peptic ulcer had endoscopic hemostasis and were randomly assigned to the high-dose oral rabeprazole group...