AIM Curcumin has been demonstrated to have antitumor effects including radiosensitization by modulating many molecular targets including p53. Herein, we investigated the radiosensitizing effect of curcumin in p53 mutant Ewing's sarcoma (ES) cells. MATERIALS AND METHODS Cells exposed to radiation with or without curcumin were examined for transcriptional and translational levels of p53 downstr...

BACKGROUND Very high levels of ionizing radiation exposure have been associated with the development of soft-tissue sarcoma. The effects of lower levels of ionizing radiation on sarcoma development are unknown. This study addressed the role of low to moderately high levels of ionizing radiation exposure in the development of soft-tissue sarcoma. METHODS Based on the Life Span Study cohort of ...

PURPOSE The PI3K/Akt/mTOR prosurvival pathway is frequently up-regulated in soft tissue sarcoma. Mammalian target of rapamycin (mTOR) inhibitors, such as rapamycin, have recently shown clinical benefit in soft tissue sarcoma, and mTOR inhibition has also been associated with radiosensitization of carcinoma and endothelial cells. This study tested the hypothesis that rapamycin radiosensitizes so...

We describe the management and outcome of a 62-year old lady who developed severe osteoarthritis of the hip, nine years after a hindquarter amputation for radiation-induced sarcoma of the contralateral pelvis. The difficulties of stabilising the pelvis intraoperatively and the problems of postoperative rehabilitation are outlined. The operation successfully relieved her pain and restored limite...

Induction of apoptosis in Ewing's sarcoma cells by ionizing radiation is accompanied by accumulation of ubiquitinated proteins preferentially in the form of conjugates with M(r) greater than 75,000. Furthermore, enhanced antiubiquitin immunofluorescence was detected only in cells that underwent radiation-induced apoptosis, suggesting that the observed alterations in protein ubiquitination are s...

BACKGROUND Limited data exist regarding reconstructive outcomes in patients with head and neck sarcoma. METHODS A review of patients with head and neck sarcoma who underwent oncologic resection and microvascular free flap reconstruction between 2001 and 2010 was performed. RESULTS In all, 133 patients were included in the study. The overall rate of perioperative complications was 30.1%, inc...

Metastatic peritoneal sarcomatosis most commonly occurs from primary soft tissue sarcomas arising either within the abdomen or extremities. Metastatic peritoneal sarcomatosis from an osteosarcoma is extremely rare; only six cases have previously been reported. We report the first case of metastatic peritoneal sarcomatosis originating from radiation-induced osteoblastic osteosarcoma in a 22-year...