Introduction: Chemoradiation is a well-established protocol for management of localized esophageal cancer. However, some early and late toxicities are associated with this therapy. Plan evaluation in term of normal tissue complication probability (NTCP) may help clinicians to tailor this therapy more individually. Given the variety of present radiobiological models, the choice...

it is now universally accepted that dna is the main target for damages caused by physical and chemical genotoxicants. although there are different methods to measure directly the induced dna damages but due to fast repair processes in cellular environment, most of the damages would be repaired even before sampling, therefore processed dna damages, i.e. damages left unrepaired after acting repai...

There are many tools available that are used to evaluate a radiotherapy treatment plan, such as isodose distribution charts, dose volume histograms (DVH), maximum, minimum and mean doses of the dose distributions as well as DVH point dose constraints. All the already mentioned evaluation tools are dosimetric only without taking into account the radiobiological characteristics of tumors or OARs....