In internal radionuclide therapy, a growing interest in voxel-level estimates of tissue-absorbed dose has been driven by the desire to report radiobiologic quantities that account for the biologic consequences of both spatial and temporal nonuniformities in these dose estimates. This report presents an overview of 3-dimensional SPECT methods and requirements for internal dosimetry at both regio...

PURPOSE Radionuclide reporter gene imaging holds promise for non-invasive monitoring of transplanted stem cells. Thus, the feasibility of utilizing recombinant baculoviruses carrying the sodium iodide symporter (NIS) reporter gene in monitoring stem cell therapy by radionuclide imaging was explored in this study. METHODS Recombinant baculoviruses carrying NIS and green fluorescent protein (GF...

Radiometals are the mainstay of both diagnostic and therapeutic nuclear medicine because the choice of radionuclide is primarily dictated by nuclear decay characteristics rather than chemistry. (99m)Tc is the most frequently used diagnostic radionuclide and requires coordination in a diversity of chemical disguises to permit imaging of a variety of tissues and disease states. Therapeutic nuclea...

Correspondence to: Dr Constantinos Anagnostopoulos, Royal Brompton Hospital, Sydney St, London SW3 6NP, UK; c.anagnostopoulos@ rbh.nthames.nhs.uk . . . . . . . . . . . . . . . . . . . . . . . 1 BACKGROUND Radionuclide myocardial perfusion imaging uses an intravenous radiopharmaceutical to image myocardial perfusion during stimulation of the perfusion system and at rest. The images are acquired ...

as a nuclear approach, positron emission tomography (pet) is a functional imaging technique which is based on the detection of gamma ray pairs emitted by a positron-emitting radionuclide. there are certain limitations to this technique such as normal tissue uptake. therefore, it has been recommended that patients prepare before scanning. fasting for a short while before pet imaging is an exampl...

Radionuclide imaging studies are routinely used to evaluate patients suspected of having musculoskeletal infection. Three-phase bone imaging is readily available, relatively inexpensive, and very accurate in the setting of otherwise normal bone. Labeled leukocyte imaging should be used in cases of “complicating osteomyelitis” such as prosthetic joint infection. This test also is useful in clini...