BACKGROUND The purpose of this study was to develop intraperitoneal hyperthermic therapy based on magnetic fluid hyperthermia, nanoparticle-wrapped cisplatin chemotherapy, and magnetic particles of albumin. In addition, to combine the multiple-killing effects of hyperthermal targeting therapy, chemotherapy, and radiotherapy, the albumin-nanoparticle surfaces were linked with radionuclide (188)R...

introduction: due to the anti-proliferative properties of platinum group-thiosemicarbazone complexes, the production of 191os-labeled 2-acetyl pyridine 4-n-methylthiosemicarbazone (191os-apmts) was investigated. methods: [191osmium (t½= 15.4d) was produced via the 190os(n,γ)191os nuclear reaction using enriched target irradiated with thermal neutrons. reaction of in-house synthesized 2-acetylpy...

introduction: rheumatoid arthritis (ra) is the most common autoimmune disease, leading to the destruction of the joints and causing pain, disability, and immobility in the patients. radiosynovectomy (rsv) has been applied as an effective treatment for the patients with resistant synovitis after failure of long-term pharmacotherapy and intra-articular steroid injection for more than 50 years. se...

Novel biodegradable Poly (L-lactic acid) (PLLA) microspheres containing ytterbium were designed for intra-tumoral radiotherapy, especially for radioembolization. 175Yb possess both therapeutic beta and diagnostic gamma radiations. In this work, process to make ready radiomicrospheres 175Yb(acac)3-loaded PLLA for more consideration has been investigated. The radiomicrospheres were prepared with ...

Novel biodegradable Poly (L-lactic acid) (PLLA) microspheres containing ytterbium were designed for intra-tumoral radiotherapy, especially for radioembolization. 175Yb possess both therapeutic beta and diagnostic gamma radiations. In this work, process to make ready radiomicrospheres 175Yb(acac)3-loaded PLLA for more consideration has been investigated. The radiomicrospheres were prepared with ...

Quality control (QC) procedures should always be performed following radiopharmaceutical preparation and prior to patient administration. The main aim of QC is to ensure optimal radiopharmaceutical product properties except for some short half-life tracers such as some positron emission tomography (PET) imaging probs. by dispensing a radiopharmaceutical of the highest quality the risk of having...

Introduction Artificial and natural radionuclides are found in diverse environmental compartments, such as water, soil, rocks, vegetables, animals, and human body tissues. As such, humans and environments are at constant exposure of these radiation types. In this research investigated specific activities of radionuclide and dose assessment of some species of mushrooms. Materials and Methods In ...

Copper-64 is a useful radioisotope for positron emission tomography (PET). Due to the wide range of applications, the demand of 64Cu with low metallic impurities is increasing. Here we report a simple method for the efficient production of high specific activity 64Cu using a cyclotron for biomedical application. We designed new equipment based on the plating of enriched 64Ni as the target, and ...

Different phosphates and phosphonates have shown excellent coating ability toward magnetic nanoparticles, improving their stability biocompatibility which enables biomedical application. The hyperthermia efficiency of (IDP IHP) (MDP HEDP) coated Fe3O4 nanoparticles (MNPs) were evaluated in an alternating field. For a deeper understanding hyperthermia, the behavior investigated MNPs non-alternat...

introduction: [64cu]diacetyl-bis(n4-methylthiosemicarbazone) ([64cu]atsm) is a well-established hypoxia imaging tracer with reproducible production and significant specifity. in this work the high yield production and quality control as well as imaging studies in healthy rabbits is reported. methods: copper-64 produced via the 68zn(p,an)64cu nuclear reaction (30 mev protons at 180 µa) was used...