INTRODUCTION: The results of studies clinical potential a new domestic radiopharmaceutical 177 Lu-DOTA-PSMA in patients with metastatic castration-resistant prostate cancer are presented this article. OBJECTIVE: pharmacokinetics, safety and tolerability were studied. Tolerability increasing activities — 5.0, 7.5 10.0 GBq was investigated. MATERIALS AND METHODS: study included 12 cancer, who pro...

this radionuclide is almost exclusively produced from the decay of its parent 99mo. 99mtc is themost available and important nuclide used as a diagnostic agent in nuclear medicine. to develop anewly practical 99mtc generator using ( n,y ) 99mo, an inorganic polymer adsorbent has beendeveloped framed with oxygen-zirconium-chlorine bonds with a high adsorption of mo, thepolyzirconium adsorbent wa...

The Cyclotron Facil ity at Mount Sinai Medical Center is involved in a program of radionuclide production culminating with the preparation of short-l ived radiopharmaceutical agents requested for cl inical evaluation. The increas ing cl inical "in-house" demand for short-lived, positronemitting radiopharmaceutical compounds has necessitated an efficient production schedule requiring unique modi...

One of the early promises of PET was that it would be quantitative (1), as opposed to imaging modalities such as x-ray CT, MRI, or SPECT, in which quantification is more of a challenge than in PET. By quantitative is meant that a raw PET signal can be transferred into absolute activity concentrations of the radiopharmaceutical in all tissues in units of, for example, kBq/cm3. In this sense, PET...

OBJECTIVE To determine whether combining isosulfan blue dye with a radiopharmaceutical agent will increase intraoperative detection of sentinel nodes (SNs) in patients with early-stage melanoma. PATIENTS AND DESIGN Clinical trial with a consecutive sample. Eighty-seven patients with clinical stage I melanoma underwent preoperative lymphoscintigraphy with 1 of 3 radiopharmaceutical agents to i...

18Fluoromethylcholine (18F-Choline, 18F-FCH) has been produced using a home-made automatic synthesiser at 30 MeV Cyclotron Centre, 108 Military Central Hospital. In order to be licensed for patients, the 18F-FCH radiopharmaceutical needs meet required quality specifications listed in pharmacopeia. The objective of this study was build up analytical procedure and perform control followed EuPh201...