Current radiotracers for positron emission tomography imaging of choline metabolism have poor systemic metabolic stability in vivo. We describe a novel radiotracer, [(18)F]fluoromethyl-[1,2-(2)H(4)]-choline (D4-FCH), that employs deuterium isotope effect to improve metabolic stability. D4-FCH proved more resistant to oxidation than its nondeuterated analogue, [(18)F]fluoromethylcholine, in plas...

introduction: in the current study we evaluated the incremental value of lateral pelvic lymphoscintigraphy imaging of endometrial or cervical cancer patients who underwent sentinel node mapping. methods: operable endometrial and cervical cancer patients without clinical or paraclinical evidence of lymph node involvement were included in the study. the day before surgery the patients were sent ...

Decades after its discovery, positron emission tomography (PET) remains the premier tool for imaging neurochemistry in living humans. Technological improvements in radiolabeling methods, camera design, and image analysis have kept PET in the forefront. In addition, the use of PET imaging has expanded because researchers have developed new radiotracers that visualize receptors, transporters, enz...

we reported a 35 year old breast cancer patient who was referred to our nuclear medicine department for sentinel node mapping. she was planned to undergo mastectomy and lymphatic mapping. a dose of tc-99m phytate was injection in the peri-areolar region in an intra-dermal fashion. two hours post-injection no sentinel node was visible in the axilla. due to a high liver uptake, inadvertent intra-...

PET provides a uniquely sensitive and powerful means for studying a clinically relevant protein target within the brain, provided that an adequately specific and sensitive radiotracer is available. Interesting targets, which include neurotransmitter receptors, neurotransmitter transporters, enzymes, and plaques, far exceed the availability of effective radiotracers. Most PET radiotracers are de...

A woman with squamous cell carcinoma of the uterine cervix, status post-irradiation therapy, was evaluated for skeletal metastasis. Technetium-99m hydroxy methylene diphosphonate bone images showed an area of abnormal radiotracer localization in the left abdomen corresponding to the descending colon. Contrast radiographic study using gastrograffin enema confirmed a large colovesical fistula bet...