Very little is known concerning the changes that occur in living tissue following the injection of solutions of an “active deposit’’ of radium emanation. This investigation was undertaken to determine what changes occur in the principal organs of the animal body following such a treatment, and to afford data that might act as a guide in the treatment of certain types of cancer, in which the sol...

In 2004, docetaxel was approved for the treatment of metastatic castration-resistant prostate cancer (mCRPC). For the next several years, there was a lull in drug approvals. However, from 2010 onwards, 5 additional therapies have been approved on the basis of showing a survival benefit in phase III studies. These agents include sipuleucel-T, cabazitaxel, abiraterone, enzalutamide and (most rece...

Prostate cancer is the most common malignant disease in men. Several therapeutic agents have been approved during the last 10 years. Among them, radium-223 dichloride (Xofigo®) is a radioactive isotope that induces irreversible DNA double-strand breaks and consequently tumor cell death. Radium-223 dichloride is a calcium-mimetic agent that specifically targets bone lesions. Radium-223 dichlorid...

manner that a medical practitioner will have not only no difficulty in following the author, but also will positively enjoy reading him. The author first of all deals with the physics of radium: next the apparatus and means of application, then the sensitivity of the tissues to radium, and. proceeds to deal with malignant growths in various situations, which are suitable for radium therapy. The...

The discovery of radium by Madame Curie in 1898 opened up a field of physical research the limits of which it is impossible to see. Although it was found at an early stage that radium had a definite action upon living tissues, this appeared to be purely destructive, and it is only recently that the selective action of radium upon cancer cells has been adequately demonstrated. Depending as it do...

Exploration of oil and natural gas from shale deposits can bring to the surface radioactivity. Naturally occurring Uranium-238 and Thorium-232 as part of their decay chains can produce radium isotopes, which are themselves precursors of radon gas. Due to the solubility of radium and its contaminated impact on the environments and health concerns, regulations on the levels of Ra226 and Ra228 in ...

Radium has been described (I have forgotten by whom,) as the most potent element which has been yet discovered for the production of discontent in the medical profession. It was hailed at first as a panacea for all ills. Although it has not fulfilled the hopes based upon it by those early enthusiasts, it has opened up new fields in the treatment of disease, especially malignant disease, but eve...

I t is well known that radium rays, as well as x-rays, are capable of affecting the living cell. Bergoni~ and Tribondeau 1 from extensive experimental studies made the generalization 2,3 that: "Immature cells and cells in an active state of division are more sensitive to the x-rays than are cells which have already acquired their fixed adult, morphological or physiological characters. ''2 Subse...

Background and Purpose. Radium-223 dichloride (Xofigo®, Bayer HealthCare Pharmaceuticals Inc.) is the first α-particle emitter therapeutic agent approved by the FDA, with benefits in overall survival and delay in symptomatic skeletal event for patients with metastatic castrate-resistant prostate cancer (CRPC). Recent post hoc analyses of the phase III ALSYMPCA trial support the previously estab...

BACKGROUND The economic value of unconventional natural gas resources has stimulated rapid globalization of horizontal drilling and hydraulic fracturing. However, natural radioactivity found in the large volumes of "produced fluids" generated by these technologies is emerging as an international environmental health concern. Current assessments of the radioactivity concentration in liquid waste...