Background The sensory innervation of the lower jaw mainly depends on third root trigeminal nerve, mandibular nerve (V3). aim this single-center, prospective, randomized, double-blind, placebo-controlled study was to evaluate effectiveness bilateral V3 block for postoperative analgesia management in osteotomies. Methods 107 patients undergoing surgery (75 scheduled osteotomies and 32 mandible f...

Methods. This was a randomized, double-blind, placebo-controlled trial. Subjects were randomized to receive either 100 mg of morphine (MS) or placebo (PLCB) with the spinal injection of bupivacaine and fentanyl. Assessments included need for supplementation during labour analgesia, use of pain medications for 24 h after delivery, and side-effects. The primary endpoint was the rate of breakthrou...

BACKGROUND It has been argued that placebos may not have important clinical impacts in general. However, there is increasing evidence of a publication bias among trials published in journals. Therefore, we explored the potential for publication bias in randomized trials with active treatment, placebo, and no-treatment groups. METHODS Three-armed randomized trials of acupuncture, acupoint stim...

OBJECTIVES Treatment of Plasmodium falciparum malaria with sulfadoxine-pyrimethamine (SP) is followed by a sharp rise in the prevalence and density of gametocytes. We did a randomized trial to determine the effect of treatment of asymptomatic infections with SP or SP plus one dose of artesunate (SP+AS) on gametocyte carriage. DESIGN The study was a three-arm open-label randomized trial. We ra...

OBJECTIVE Axial spondyloarthritis (axial SpA) is characterized by inflammation of the spine and sacroiliac joints and can also affect extraarticular sites, with the most common manifestation being uveitis. Here we report the incidence of uveitis flares in axial SpA patients from the RAPID-axSpA trial, including ankylosing spondylitis (AS) and nonradiographic (nr) axial SpA. METHODS The RAPID-...

BACKGROUND AND PURPOSE Restless Legs Syndrome (RLS) is a primary disorder of sensation that affects sleep and has been associated with iron deficiency. The purpose of this study was to determine if symptomatic RLS patients with low-normal serum ferritin levels benefit from oral iron replacement. PATIENTS AND METHODS This was a randomized, placebo-controlled, double-blinded study. Eligible pat...

OBJECTIVE To examine the significant "placebo effect" in a randomized, double-blind, placebo-controlled interstitial cystitis/bladder pain syndrome trial. Randomized clinical trials are the reference standard for therapeutic impact assessment. However, proving efficacy of treatments for interstitial cystitis/bladder pain syndrome with rigorous placebo-controlled trials is difficult due to a sig...

BACKGROUND We examined the effects of disulfiram versus placebo on cocaine dependence in buprenorphine-maintained subjects. METHODS Opioid and cocaine dependent subjects (n = 20) were induced onto buprenorphine maintenance, then randomized to disulfiram (250 mg q.d. ; n = 11) or placebo (n = 9) treatment for 12 weeks. RESULTS Groups were comparable at baseline on demographic measures and on...

In a randomized, head-to-head, placebo-controlled trial, we enrolled adults with obesity (body-mass index [the weight in kilograms divided by the square of height meters], 32 to 43) who did not have diabetes. After an 8-week low-calorie diet, participants were randomly assigned for 1 year one four strategies: moderate-to-vigorous–intensity exercise program plus placebo (exercise group); treatme...

Abstract Background Major depressive disorder is the second leading cause of years lost to disability worldwide. Anyu Peibo Capsule has been shown be effective and safe in phase II trials. Methods This clinical study a multi-center, randomized, double-blinded, placebo-controlled, parallel-group, III trial China. The aim test whether administration compared placebo improves outcomes adults (aged...