Abstract Background Major depressive disorder is the second leading cause of years lost to disability worldwide. Anyu Peibo Capsule has been shown be effective and safe in phase II trials. Methods This clinical study a multi-center, randomized, double-blinded, placebo-controlled, parallel-group, III trial China. The aim test whether administration compared placebo improves outcomes adults (aged...

BACKGROUND Trigeminal neuralgia (TN) is a rare severe unilateral facial pain condition. Current guidelines in trigeminal neuralgia management recommend sodium channel blockers--carbamazepine or oxcarbazepine--as the first-line treatment. However, the currently available drugs are often associated with poor tolerability resulting in sub-optimal pain control. CNV1014802 is a novel sodium channel ...

BackgroundBerotralstat (BCX7353) is a recently approved, oral, once-daily kallikrein inhibitor for hereditary angioedema (HAE) prophylaxis. In the APeX-2 trial, berotralstat reduced HAE attack rates over 24 weeks, with favorable safety and tolerability profile.ObjectiveEvaluate safety, tolerability, effectiveness 48 weeks.MethodsAPeX-2 phase 3, parallel-group, multicenter trial (NCT03485911) in...

861Huang SM and Woodcock J. (2009). Transporters in drug development:advancing on theCritical Path. Nat Rev Drug Discov. 2010 Mar;9(3):175-6Irving G., Pénzes J., Ramjattan B., et al (2011). A randomized, placebo-controlled phase 3trial (study SB-767905/013) of alvimopan for opioid-induced bowel dysfunction inpatients with non-cancer pain. J Pain. 12:175-84Jansen J.P., Lo...

objective: premenstrual syndromes (pms) affecting 20-40% of women of reproductive age. the aim of this double blind and placebo controlled trial was to investigate whether femicofort a supplement contains vitamin b6, vitamin e and evening primrose oil could relieve symptoms of pms. method: this was a randomized and double blind clinical trial. the trial was conducted between november 2009 and a...


 The results of 1 randomized controlled trial did not find a difference in functional status (6-minute walk distance and New York Heart Association class), hand grip strength, or health-related quality life for patients who underwent transcatheter aortic valve implantation treated with iron isomaltoside versus placebo.
 There was (1.4%) hypersensitivity reaction episode chest pain th...

UNLABELLED The typical placebo response (ie, the nonspecific effects in the placebo group including benign natural course, regression to the mean, expectation/conditioning effects, and others) in randomized trials in complex regional pain syndrome (CRPS) is unknown. We recently observed a surprising near-absence of placebo response in a randomized controlled trial we conducted on patients with ...