BACKGROUND Addiction relies on persistent alterations of neuronal properties, which depends on gene regulation. Activity-regulated cytoskeleton-associated protein (Arc) is an immediate early gene that modulates neuronal plasticity underlying learning and memory. Its role in cocaine-induced neuronal and behavioral adaptations remains elusive. METHODS Acute cocaine-treated mice were used for qu...

PURPOSE To compare low dose volume and integral dose of various rotational arc radiation therapy modalities, including helical tomotherapy (HT) and other volumetric modulated arc therapies (VMAT). METHODS A digital cylindrical phantom and an anthropomorphic pelvic phantom were used in the study. HT treatment was planned on TomoTherapy Planning Station (Accuray) and VMAT plans were generated o...

In regard to the tectonic history of the Lachlan Fold Belt, Aitchison and Buckman (2012) argued that "numerous aspects of the observed geology appear to be incompatible with the existing model" and that an "alternative model envisages arc-continent collision events (quantum tectonics) as a primary means of largescale continental growth". My purpose is to challenge these arguments and to questio...

Nanocrystals in the lower-nanometer-size range are attracting growing interest due to their unique properties. A simple and versatile atmospheric direct current mini-arc plasma source has been developed to produce nanoparticles as small as a few nanometers. The nanoparticles are formed by direct vaporization of solid precursors followed by a rapid quenching. Both semiconductor tin oxide and met...

Neuroinflammation is associated with a variety of neurological and pathological diseases, such as Alzheimer's disease (AD), and is reliably detected by the presence of activated microglia. In early AD, the highest degree of activated microglia is observed in brain regions involved in learning and memory. To investigate whether neuroinflammation alters the pattern of rapid de novo gene expressio...

The hippocampus is hypothesized to support rapid encoding of ongoing experience. A critical prerequisite for such function is the ability to readily recruit enduring synaptic plasticity in hippocampal neurons. Hippocampal long-term potentiation (LTP) and memory consolidation require expression of the immediate-early gene (IEG) Arc. To determine whether Arc transcription could be driven by limit...

Abstract. Since electromagnetic (EM) noise resulting from an arc discharge disturbs other electric devices, parameters on electromagnetic compatibility, as well as lifetime and reliability, are important properties for electrical contacts. To clarify the characteristics and the mechanism of the generation of the EM noise, the current noise up to GHz band frequency generated by slowly breaking c...