conclusions these data suggest that am404’s concentration-time profile in the brain is similar to those of acetaminophen and its other metabolites. measurement of blood acetaminophen concentration seems to reflect the concentration of the prospective bioactive substance, am404. results the maximum plasma concentrations of acetaminophen and am404 in the rat brain were 15.8 µg/g and 150 pg/g, res...

the short and long term effects of chromium toxicity on brain catecholamines and acetylcholinesterase levels were investigated. rats were injected daily with varying amounts of chromium. the short term (2 h) administration of chromium (8 mmol/kg) reduced catecholamines level of cerebellum, mid-brain and brain-cortex by 22.8, 19.4 and 21.2% respectively. acetylcholinesterase activity was also re...

this study aimed to observe the protective effects of sufentanil pretreatment on rat cerebral injury during cardiopulmonary bypass (cpb) and to explore the underlying mechanism. twenty-four male adult sprague dawley (sd) rats were divided into 4 groups. then, the rat cpb model was established. a 14g trocar was inserted into the atrium dextrum. for rats in s1 and s5 groups, sufentanil (1 µg•kg-1...

Background and objectives: Diazinon (DZN), an organophosphate insecticide, is widely used in agriculture. One of its deleterious effects is on neural systems. Diazinon with acetylcholinesterase activity and lipid peroxidation induces brain toxicity . Ginger, as a medicinal plant, has antioxidant and anti-imflammatory properties. The aim of present study was to evaluate...

(1) Background: The findings of our recent in vivo study indicated that the oral administration oenothein B, a unique macrocyclic ellagitannin, activated extracellular signal-regulated kinase (ERK) 2 and cAMP response element-binding protein (CREB) mouse brain. A large hydrophilic B is unable to reach brain, suggesting any metabolite(s) might function (2) Results: addition culture medium rat co...

You have accessJournal of UrologyBladder & Urethra: Anatomy, Physiology Pharmacology (MP08)1 Sep 2021MP08-01 BRAIN α7 NICOTINIC ACETYLCHOLINE RECEPTORS ARE INVOLVED IN SUPPRESSION OF THE RAT MICTURITION REFLEX VIA GABA Takahiro Shimizu, Yohei Suo Zou, Hideaki Ono, Yurika Hata, Masaki Yamamoto, Takaaki Aratake, Shogo Youichirou Higashi, Takashi Karashima, Masashi Honda, and Motoaki Saito Shimizu...

Objective(s): Cognitive defects such as learning and memory impairment are amongst the most repetitious sequelae after sever and moderate traumatic brain injury (TBI). It was suggested that ellagic acid (EA), an innate phenol product, display neuroprotective properties against oxidative and inflammatory damages after brain injury. The object of the current study was therapeutic properties of EA...

introduction: prolonged and intermittent oxygen pre-exposure is associated with protection against ischemic reperfusion (ir) injury. in the current study, attempts were made to investigate the relationship between exposure to prolonged and intermittent normobaric hyperoxia (nbho) and expression of excitatory amino acids transporters (eaats) and tnf-α level. method: rats were divided into four m...

background susceptibility-weighted imaging (swi) is extremely sensitive in the detection of superparamagnetic iron oxide (spio) nanoparticle-labeled cells. however, no study has compared molecular imaging for stem cell detection using swi and other mri pulse sequences. objectives this study aims to assess the sensitivity of swi in detecting spio nanoparticle-labeled, human bone marrow-derived m...