Objective: It was aimed to investigate the antigenotoxic effect of Ganoderma lucidum against damage caused by lipopolysaccharide (LPS) in rat bone marrow cells micronucleus test and comet analysis.
 Method: In experiment, 28 Wistar albino female rats were used 4 groups formed. Only physiological saline applied control group. A single dose 7.5 mg/kg LPS administered intraperitoneally LPS+ (...

The contents of nucleic acids in rat liver and hepatoma mitochondria and the physico-chemical properties on DNA’s isolated from these mitochondria were comparatively investigated. The results are briefly summarized as follows. 1. The contents of DNA and RNA per mg protein of the hepatoma cell mitochondria were about 10 and 2 to 4 times higher than those of rat liver mitochondria, respectively. ...

Several reports on amorphous silica nanomaterial (aSiO2 NM) toxicity have been questioning their safety. Herein, we investigated the in vivo pulmonary of four variants aSiO2 NM: SiO2_15_Unmod, SiO2_15_Amino, SiO2_7 and SiO2_40. We focused alterations lung DNA protein integrity, gene expression following single intratracheal instillation rats. Additionally, a short-term inhalation study (STIS) w...

Abnormal patterns of DNA methylation are observed in several types of human cancer. While localized DNA methylation of CpG islands has been associated with gene silencing, the effect that genome-wide loss of methylation has on tumorigenesis is not completely known. To examine its effect on tumorigenesis, we induced DNA demethylation in a rat model of human chondrosarcoma using 5-aza-2-deoxycyti...

Cerebral dopamine neurotrophic factor (CDNF) and mesencephalic astrocyte-derived (MANF) are involved in neuroprotection mitigating endoplasmic reticulum (ER) stress the brain peripheral organs. In earlier work, an increase histone acetylation, following treatment with epigenetic modulator, valproic acid, was associated induction of CDNF MANF cultured cells rat brain. These findings prompted inv...

We have previously reported that 7,12-dimethylbenz(a)an thracene (DMBA), given i.v. 24 hr after partial hepatectomy when DNA replication is maximal, binds tightly to DNA, inhibits its synthesis, and induces neoplastic changes in regenerating rat liver. We now report that DMBA injected i.v. 5 hr after partial hepatectomy (i.e., during the early prereplicative phase) inhibits DNA synthesis for at...

We have previously reported that 7,12-dimethylbenz(a)an thracene (DMBA), given i.v. 24 hr after partial hepatectomy when DNA replication is maximal, binds tightly to DNA, inhibits its synthesis, and induces neoplastic changes in regenerating rat liver. We now report that DMBA injected i.v. 5 hr after partial hepatectomy (i.e., during the early prereplicative phase) inhibits DNA synthesis for at...

We have previously reported that 7,12-dimethylbenz(a)an thracene (DMBA), given i.v. 24 hr after partial hepatectomy when DNA replication is maximal, binds tightly to DNA, inhibits its synthesis, and induces neoplastic changes in regenerating rat liver. We now report that DMBA injected i.v. 5 hr after partial hepatectomy (i.e., during the early prereplicative phase) inhibits DNA synthesis for at...