Injection of a hyperphysiological dose of 17P-estradiol to the rat elicits a translocation of the cytoplasmic estrogen receptor in the kidney. This is followed, a few hours later, by an increase in the rate of ornithine aminotransferase synthesis. This increase, in turn, causes the enzyme activity to rise also a few hours later. Growth of rat kidney tumor MK3 has delayed the induction of ornith...

The importance of estrogens for the regulation of longitudinal bone growth is unequivocal. However, any local effect of estrogens in growth plate cartilage has been debated. Recently, several enzymes essential for estrogen synthesis were shown to be expressed in rat growth plate chondrocytes. Local production of 17beta-estradiol (E2) has also been demonstrated in rat costal chondrocytes. We aim...

Stres oksidatif dapat menyebabkan infertilitas melalui berbagai mekanisme, yaitu ketidakseimbangan antioksidan dan radikal bebas, sehingga meningkatkan kerusakan seluler yang disebabkan oleh Reactive oxygen species (ROS). Monosodium glutamat (MSG) adalah garam natrium glutamat, digunakan sebagai bahan tambahan makanan penguat cita rasa. Pemberian MSG tikus secara oral peningkatan Oxygen Species...

Sexual behavior in many mammals is characterized by its dependence on circulating titer of sex hormones and sexual dimorphism. Sexual dimorphism in female and male behavior depends, not on genetic sex but on early actions of sex hormone at a specific period during ontogenesis in each species. The period, termed the critical period for the brain sex differentiation, spans over gestational day 18...

A recent report by Lyttle et al. (Lyttle, C. R., Medlock, R. L., and Sheehan, D. M. (1984) J. Biol. Chem. 259, 2697-2700) suggested that nuclear type II sites in the rat uterus are of eosinophil origin and may represent [3H]estradiol binding to eosinophil peroxidase. To further evaluate this hypothesis we examined the response of nuclear type II sites to estrogen under conditions where eosinoph...

Estrogen deficiency is associated with increased incidence of cardiovascular diseases. But merely estrogen supplementary treatment can induce many severe complications such as breast cancer. The present study was designed to elucidate molecular mechanisms underlying increased susceptibility of arrhythmogenesis during myocardial infarction with estrogen deprivation, which provides us a new targe...

Background and Purpose—Because of their mixed estrogen-agonist and estrogen-antagonist properties, selective estrogen receptor modulators (SERMs) are considered promising substitutes for hormone replacement therapy. Raloxifene and other SERMs confer estrogen-like cardiovascular protective effects but lack the carcinogenic activity of exogenous estrogen. However, little is known about the cerebr...

BACKGROUND AND PURPOSE Because of their mixed estrogen-agonist and estrogen-antagonist properties, selective estrogen receptor modulators (SERMs) are considered promising substitutes for hormone replacement therapy. Raloxifene and other SERMs confer estrogen-like cardiovascular protective effects but lack the carcinogenic activity of exogenous estrogen. However, little is known about the cerebr...

BACKGROUND Uterine fibroids or leiomyoma are a common benign smooth muscle tumor. The tumor growth is well known to be estrogen-dependent. However, the molecular mechanisms of its estrogen-dependency is not well understood. METHODS Differentially expressed genes in human uterine fibroids were either retrieved from published papers or from our own statistical analysis of downloaded array data....