Health risks from space radiations, particularly from densely ionizing radiations, represent an important challenge for long-ranged manned space missions. Reliable methods are needed for scaling low-LET to high-LET radiation risks for humans, based on animal or in vitro studies comparing these radiations. The current standard metric, relative biological effectiveness (RBE) compares iso-effect d...

Purpose Uncertainty in the Relative Biological Effectiveness (RBE) of heavy charged particles compared to photons remains one of the major uncertainties in particle therapy. As RBEs depend strongly on clinical variables such as tissue type, dose, and radiation quality, more accurate individualised models are needed to fully optimise treatments. MethodsWe have developed a model of DNA damage and...

BACKGROUND The assessment of RBE quantity in the treatment of cancer tumors with proton beams in treatment planning systems (TPS) is of high significance. Given the significance of the issue and the studies conducted in the literature, this quantity is fixed and is taken as equal to 1.1. OBJECTIVE The main objective of this study was to assess RBE quantity of proton beams and their variations...

Radiotherapy of solid tumors with charged particles holds several advantages in comparison to photon therapy; among them conformal dose distribution in the tumor, improved sparing of tumor-surrounding healthy tissue, and an increased relative biological effectiveness (RBE) in the tumor target volume in the case of ions heavier than protons. A crucial factor of the biological effects is DNA dama...

The objective of microdosimetry was, and still is, to identify physical descriptions of the initial physical processes of ionising radiation interacting with biological matter which correlate with observed radiobiological effects with a view to improve the understanding of radiobiological mechanisms and effects. The introduction of therapy with particles starting with fast neutrons followed by ...

We present a new task model for the real-time execution of event-driven tasks in which no a priori characterization of the actual arrival rates of events is known; only the expected arrival rates of events is known. We call this new task model rate-based execution (RBE), and it is a generalization of the common sporadic task model. The RBE model is motivated naturally by distributed multimedia ...

The effects of pineapple juice (PJ), pineapple shell extract (PSE) and rice bran extract (RBE) on browning in the banana slices and puree compared with citric acid solution (pH 3.8) (PH) and distilled water (DW) were investigated by measuring the color changes of the banana slices and puree. RBE treated banana slices had lower browning value than those treated with PJ, PSE, PH and DW after stor...

There are few reports on the biological homogeneity within the spread-out Bragg peak (SOBP) of proton beams. Therefore, to evaluate the relative biological effectiveness (RBE) and the oxygen enhancement ratio (OER), human salivary gland tumor (HSG) cells were irradiated at the plateau position (position A) and three different positions within a 6-cm-wide SOBP (position B, 26 mm proximal to the ...

Besides the absorbed dose, the Relative Biological Effectiveness (RBE) is the most important quantity in treatment planning with ion radiotherapy. The RBE depends on many different parameters, such as: the biological endpoint, the dose, the particle type and energy and the tissue under consideration. In consequence, the RBE will be different at any location in the treatment field. As the biolog...

The present study was undertaken to determine relative biological effectiveness (RBE) values for simulated solar particle event (SPE) radiation on peripheral blood cells using Yucatan minipigs and electron-simulated SPE as the reference radiation. The results demonstrated a generally downward trend in the RBE values with increasing doses of simulated SPE radiation for leukocytes in the irradiat...