Patients with Mild Cognitive Impairment (MCI) not converted to dementia at one to three years follow-up represent a heterogeneous group across studies, by including 'late converters' but also patients without any neurodegenerative disease. We tested the hypothesis that the combination of memory and brain metabolic assessment could identify subgroups of memory decliners (MCI/Decl) and non-declin...

background: the nonamnesic type of mild cognitive impairment (na?mci) is predementia state with subtle decline incognitive domains except memory. although cognitive rehabilitation (cr) has been investigated in amnesic type of mci, we could not find any trial that rehabilitated na?mci exclusively. we studied the effectiveness of cr on na?mci. materials and methods: this study was a blinded, rand...

Mild cognitive impairment (MCI) and mild Alzheimer’s disease (AD) progressively compromise various aspects of cognition essential for everyday functioning independence, including the ability to drive. Reliable measures driving performance can be obtained using simulators designed evaluate fitness This technology may also provide methodology evaluation in a real-world setting, thereby filling in...

In this report we evaluated the clinical performance of APOE genotyping and three protein biomarkers (total tau, beta-amyloid(1-42), and tau phosphorylated at threonine 181) in a prospective multicenter study using the INNO-BIA AlzBio3 assay applied on Luminex platform. Concentration of biomarkers of Alzheimer's disease in cerebrospinal fluid (CSF) was measured with multiplexing technology (n=2...

A group of 94 nondemented patients self-referred to an outpatient memory clinic for memory difficulties were studied to determine the incidence of single versus multi-domain mild cognitive impairment (MCI) using Petersen criteria. Fifty-five community dwelling normal controls (NC) participants without memory complaints also were recruited. Tests assessing executive control, naming/lexical retri...

Prior work has shown that white matter fiber integrity decreases in Alzheimer’s disease (AD) and mild cognitive impairment (MCI). This integrity can be quantified using diffusion tensor imaging techniques, which describe the anisotropic water movement in the brain. It is important to identify features that can predict the chance of conversion from MCI to AD within a certain time frame. In this ...

OBJECTIVES A mass casualty incident (MCI) may strain a health care system beyond surge capacity, affecting patterns of care for casualties and other patients. Prior studies of MCIs have assessed clinical care for casualty patients, but have not examined outcomes or expenditures for noncasualty inpatients in the same time period. METHODS This was a retrospective analysis of administrative hosp...

BACKGROUND/AIMS Mild cognitive impairment (MCI) is associated with an increased risk of Alzheimer's disease (AD). It would be advantageous to be able to distinguish the characteristics of those MCI patients with a high probability to progress to AD if one wishes to monitor the disease development and treatment. METHODS We assessed the baseline MRI and maximum of 7 years clinical follow-up dat...

Mild cognitive impairment (MCI), defined as episodic memory impairment beyond what is expected in normal aging, is often associated with hippocampal atrophy (HA) and may represent incipient Alzheimer's disease. However, recent studies suggest that MCI is very heterogeneous and multiple etiologies likely exist. One possibility is small vessel cerebrovascular disease (CVD). Specifically, we hypot...

Although older adults with Mild Cognitive Impairment (MCI) show elevated rates of conversion to dementia as a group, heterogeneity of outcomes is common at the individual level. Using data from a prospective 5-year longitudinal investigation of cognitive change in healthy older adults (N = 262, aged 64-92 years), this study addressed limitations in contemporary MCI identification procedures whi...