Targeted nanoparticles have the potential to deliver a large drug payload specifically to cancer cells. Targeting requires that a ligand on the nanoparticle surface interact with a specific membrane receptor on target cells. However, the contribution of the targeting ligand to nanoparticle delivery is often influenced by non-specific nanoparticle uptake or secondary targeting mechanisms. In thi...

Abstract In December 2019, a novel respiratory tract infection, from severe acute syndrome coronavirus 2 (SARS-CoV-2), was detected in China that rapidly spread around the world. This virus possesses spike (S) glycoproteins on surface of mature virions, like other members coronaviridae. The S glycoprotein is crucial viral protein for binding, fusion, and entry into target cells. Binding recepto...

The androgen receptor (AR) is the principal therapeutic target in prostate cancer. For the past 70 years, androgendeprivation therapy (ADT) has been the major therapeutic focus. However, some patients do not benefit, and those tumorsthat do initially respond to ADT eventually progress. One recently described mechanism of such an effect is growth andsurvival-promoting effects of the ...

In article number 2200236, Zhihong Zhang, Xiang Yu, and co-workers achieve the direct size conversion of erythrocyte-derived MVs (eMVs) via incubation with an ApoA-I mimetic peptide (R4F) capable binding phospholipids. R4F modification endows eMVs SR-B1 receptor lymph node targeting functions, providing excellent drug delivery system for targeted treatment node-associated diseases.

For effective localization of functionalized nanoparticles at diseased tissues such as solid tumours or metastases through biorecognition, appropriate targeting vectors directed against selected tumour biomarkers are a key prerequisite. The diversity of such vector molecules ranges from proteins, including antibodies and fragments thereof, through aptamers and glycans to short peptides and smal...

Vascular endothelial growth factor receptor-2 (VEGFR-2); a cell surface receptor for vascular endothelial growth factors, is a key pharmacological target involved in the cell proliferation/angiogenesis. It has been revealed that VEGFR-2 induces proliferation through activation of the extracellular signal-regulated kinases pathway. In this regard, targeting the VEGFR-2 has been considered as an ...

Hepatocellular carcinoma (HCC) is the third leading cause of cancer mortality and increasing in incidence worldwide. Early detection HCC important since potentially curative therapies exist initial stages HCC; no for late-stage HCC. However, remains challenging due to lack symptoms during early stage disease. Other methods screening detecting HCC, including blood serum tests conventional imagin...

Triple-negative breast cancer (TNBC) is considered one of the most aggressive forms with poor survival rates compared to other subtypes. TNBC characterized by absence estrogen receptor alpha, progesterone receptor, and human epidermal growth factor 2, limiting those viable treatment options available patients Furthermore, due particularly high heterogeneity TNBC, conventional treatments such as...