BACKGROUND Genetic factors are the main cause of early miscarriage. This study aimed to investigate aneuploidy in spontaneous abortion by fluorescence in situ hybridization (FISH) using probes for 13, 16, 18, 21, 22, X and Y chromosomes. METHODS A total of 840 chorionic samples from spontaneous abortion were collected and examined by FISH. We analyzed the incidence and type of abnormal cases ...

Background: This is a case-control study to determine the relationship between endothelial nitric oxide synthase (eNOS) gene -786T/C polymorphism in women with unexplaiend recurrent abortion in comparison with healty women.Materials and Methods: 95 women with history of at least 2 unexplaiend recurrent abortion in the reproductive age range 20-35 years as patients group and 95 healty women (age...

Recurrent abortion is classically defined as three or more consecutive pregnancy losses, although recently more than two pregnancy losses also considered as recurrent abortions. This condition affects approximately 1% of couples at reproductive age. Recurrent pregnancy loss has been attributed to anatomic uterine pathologies, genetic defects, endocrine disorders, immunologic factors, prothrombo...

UNLABELLED Human reproduction is not considered a highly efficient biological process. Before the end of the first trimester, 30%-50% of conceptions end in spontaneous abortion. Most losses occur at the time of implantation. 15%-20% of clinical pregnancies end in spontaneous abortions. Recurrent pregnancy loss is a frustrating clinical problem both for clinicians and patients. Recurrent pregnan...

O BJECTIVE: The goal of this study was to modify and optimize the screening and diagnostic procedures of unexplained recurrent abortion. Antithyroid antibodies, parvovirus B19 (B19V) and cytomegalovirus (CMV) infections, which were usually overlooked in clinical practice of handling cases of recurrent abortion, were studied to evaluate their role in the pathogenesis of recurrent first trimester...

BACKGROUND CD46 is a complement regulatory glycoprotein. Certain polymorphic forms of the CD46 gene have been associated with recurrent pregnancy loss in the Caucasian population. We assessed the role of CD46 polymorphism in recurrent spontaneous abortion in our setting, as this has not been done on Indian subjects till date. METHODS Polymerase chain reaction-restriction fragment length polym...

Background: Uterine anomalies are thought to be one of the reasons recurrent miscarriages, and have been found in as many 10% 15% individuals who had several miscarriages. Before submitting patients another pregnancy, it is critical rule out any intrauterine abnormality. In situations pregnancy loss, office hysteroscopy has shown a highly useful technique diagnosing treating anatomical reasons....