Galectins are galactose binding proteins and, in addition, factors for a wide range of pathologies in pregnancy. We have analyzed the expression of prototype (gal-1, -2, -7, -10) and chimera-type (gal-3) galectins in the placenta in cases of spontaneous abortions (SPA) and recurrent abortions (RA) in the first trimester. Fifteen placental samples from healthy pregnancies were used as a control ...

* Corresponding author. E-mail: [email protected] Background. The aim of the study was to evaluate the association between the most common laboratory markers of thrombophilias and recurrent first-trimester spontaneous abortions. Materials and methods. During the period from November 2000 to April 2004, a case-control study was carried out at the Department of Obstetrics and Gynecology ...

The release of certain cytokines, e.g. tumour necrosis factor (TNF)-alpha, in the amniotic fluid has been suggested to be a cause of preterm birth. The predisposition to excessive liberation of cytokines from peripheral leukocytes has been shown to depend partly on the individual's HLA-DR genotype. The HLA-DR1 and -DR3 alleles have previously been reported as being associated with a TNF-alpha h...

The non-classical class I human leukocyte antigen (HLA)-G molecule was found to be predominately expressed in the extravillous cytotrophoblasts at the fetal-maternal interface during pregnancy. This molecule is critically important for successful implantation during human pregnancy. The polymorphic insertion-deletion (indel) 14-base pair (bp) site localized at the 3' untranslated region was ass...

background: evidences suggest an association between the prevalence of thyroid peroxidase (anti-tpo) and anti thyroglobulin (anti-tg) with recurrent abortions and infertility. iodine deficiency was once endemic in iran and little data is available about the prevalence of these antibodies in different groups of fertile or infertile individuals. objective: this case control study was designed to ...

BACKGROUND Antiphospholipid antibodies are associated with recurrent abortion but correlation between level of antibodies and gestational age of abortion and duration post abortion is not clear. OBJECTIVES Aim of this study was study on relation between antiphospholipid antibodies in women with recurrent abortion and their gestational age and duration post abortion. PATIENTS AND METHODS We ...