The Editorial by Hage and Iskandrian regarding ‘‘Serious complications associated with regadenoson administration for myocardial perfusion imaging: A commentary’’ (September/October 2014 issue) includes a table as a guide for serious complications associated with regadenoson administration. In the table, the authors reported whether or not each listed event occurs with exercise and/or adenosine...

Objective To use velocity encoded phase contrast MRI to determine timing of peak myocardial blood flow to establish when CMR stress perfusion imaging should be performed after injection of regadenoson.

Background The diagnostic dilemma of patients suffering from chronic obstructive pulmonary disease (COPD) presenting with symptoms equivalent to an acute coronary syndrome (ACS) and slightly elevated high sensitive troponine in the observational range (hsTnT 14-53 ng/l) is complex. Prognostic impact of elevated hsTnT demand further investigation. Comorbidities of COPD and coronary artery diseas...

Methods We identified 19 patients who underwent regadenoson stress CMR (1.5T, Philips), had MI confirmed by late gadolinium enhancement (LGE), and underwent invasive coronary angiography within 6 months of CMR. Stress perfusion images were obtained during first pass of Gadolinium contrast agent one minute after regadenoson (0.4mg IV bolus) injection, and followed by reversal with aminophylline ...

Background BOLD CMR is a non-contrast approach for examining myocardial perfusion but despite major technical advancements to date, its reliability remains weak. A key reason for this is the unpredictable cardiac motion during stress, which can lead to pronounced artifacts that confound/ mask the true BOLD signal changes during hyperemia. Recently, regadenoson has become the vasodilator of choi...

Stress testing is challenging in patients with chronic obstructive pulmonary disease (COPD). Functional capacity is generally decreased in this patient population, limiting patients' ability to achieve physiologic stress through exercise. Additionally, due to emphysematous changes, COPD patients tend to have poor acoustic windows that impair the quality and therefore diagnostic accuracy of stre...

Background Adenosine has traditionally been utilized for coronary hyperemia during myocardial perfusion assessment in adults, however regadenoson has recently become more popular [1]. With improved survival of congenital heart disease (CHD), and increased diagnosis of acquired heart disease (AHD), there’s an increasing need for assessment of myocardial perfusion in pediatrics [2]. Only dipyrida...

Background Changes in global and regional wall motion between rest and stress are important prognostic markers, uncommonly observed with vasodilator stress radionuclide myocardial perfusion imaging (MPI). Cardiac MRI (CMR) with tagging has the potential to more precisely quantify normal and abnormal ventricular wall motion responses. We herein report CMR findings in 5 very low-likelihood patien...