objective(s):eukaryotic translation initiation factor 4e (eif4e) is overexpressed in cervical cancer (cc). however, the molecular mechanisms are unclear. this study aimed to investigate the molecular mechanism of eif4e gene overexpression in cc. materials andmethods:the human papillomavirus (hpv) type 18 e7 and eif4e mrnas were measured following knock down or overexpression of e7 gene by rt-pc...

[1] Current studies of the impact of climate change mitigation options tend to scale patterns of precipitation change linearly with surface temperature. Using climate model simulations, we show a nonlinear hydrological response to transient global warming and a substantial side effect of climate mitigation. In an idealised representation of mitigation action, where we reverse the trend of globa...

with advances in genetic science, the dynamic structure of eukaryotic genome is considered as basis of gene expression regulation. long-distance communication between regulatory elements and target promoters is critical and the mechanisms responsible for this connection are just starting to emerge. chromatin insulators are key determinants of proper gene regulation and precise organization of c...

Water storage change has implications not only for the hydrological cycle, but also for sustainable water resource management in especially semi-arid river basins. Satellite/remote sensing techniques have gained increasing application in monitoring basin and regional hydrological processes in recent decades. In this study, the latest version of GRACE (Gravity Recovery and Climate Experiment) is...

Abstract. State-of-the-art global hydrological models (GHMs) exhibit large uncertainties in simulations due to the complexity, diversity, and heterogeneity of land surface subsurface processes, as well scale dependency these processes associated parameters. Recent progress machine learning, fueled by relevant Earth observation data streams, may help overcome challenges. But learning methods are...

Abstract The Mediterranean-Black Sea system consists of two semi-enclosed basins connected by the Turkish Straits. In turn, Mediterranean is to Atlantic Ocean through narrow Strait Gibraltar. hydrological cycle driven fresh water exchanges between atmosphere, continents and oceans, salty mass exchange among ocean basins. Monitoring such fluxes, especially its time evolution, essential understan...