the biologists now face with the masses of high dimensional datasets generated from various high-throughput technologies, which are outputs of complex inter-connected biological networks at different levels driven by a number of hidden regulatory signals. so far, many computational and statistical methods such as pca and ica have been employed for computing low-dimensional or hidden representat...

Intracellular protein traffic plays an important role in the regulation of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) chloride channels. Microtubule and actin-based motor proteins direct CFTR movement along trafficking pathways. As shown for other regulatory proteins such as adaptors, the involvement of protein motors in CFTR traffic is cell-type specific. Understanding motor sp...

Understanding gene interactions in complex living systems can be seen as the ultimate goal of the systems biology revolution. Hence, to fully understand disease ontology and to reduce the cost of drug development, Gene Regulatory Networks (GRN) have to be constructed. During the last decade, many GRN inference algorithms like Bayesian network that are based on genome-wide data have been develop...

Genetic differences between individuals associated to quantitative phenotypic traits, including disease states, are usually found in non-coding genomic regions. These genetic variants are often also associated to differences in expression levels of nearby genes (they are “expression quantitative trait loci” or eQTLs for short) and presumably play a gene regulatory role, affecting the status of ...

Legislators and the courts have begun to recognize the importance of how electronically stored data should be maintained and secured, and how electronic data should be differentiated from their paper analogs. Examples of some of the sweeping pieces of electronic record management legislation include the Health Insurance Portability and Accountability Act (HIPAA) of 1996, the Gramm-Leach-Bliley ...