Clinical measurements by the increment-threshold technique of W.S. Stiles are reported in five cases of age-related macular degeneration. Measurements were made on a modified Tübingen perimeter using 1 degree, short-wavelength targets presented on a red field.

Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in developed countries. The role of complement in the development of AMD is now well-established. While some studies show evidence of complement dysregulation within the eye, others have demonstrated elevated systemic complement activation in association with AMD. It is unclear which one is the primary driver ...

BACKGROUND The pathogenesis of age-related macular degeneration (AMD) remains unknown. Genetic and environmental factors are thought to be associated with AMD. Although some studies have reported familial cases of AMD in the United States, as far as we know, familial cases of AMD have rarely been reported in Japan. CASES We describe three families with two members of each family affected with...

We report a method to train individuals with central field loss due to macular degeneration to improve the efficiency of visual search. Our method requires participants to make a same/different judgment on two simple silhouettes. One silhouette is presented in an area that falls within the binocular scotoma while they are fixating the center of the screen with their preferred retinal locus (PRL...

BACKGROUND Age-related macular degeneration (AMD) is the leading cause of visual impairment and blindness in the Western World in those aged 65 and older. At present, several treatment modalities are utilised and several more are undergoing investigation in an attempt to retard the occurrence and progression of this devastating condition. AIMS To provide the non-ophthalmologist with an unders...

The purpose of this study was to evaluate the role of diminished arterial blood flow in painful disc

OBJECTIVES To better understand the effects of misinformation on eyewitnesses of different ages, older and younger adults experienced an event under intentional and incidental learning conditions in a naturalistic experiment using multiple memory tests. METHOD Following exposure to the event, which was a brief interruption of a group testing session, participants completed several memory test...

The dimensions of the Westheimer function are stable across populations and in time and vary with the eccentricity of fixation. The function is thus useful to assess whether an individual is fixing centrally and if not to estimate the degree of eccentricity of fixation. We identified both summation and inhibition-like regions in a 66-year-old woman with senile macular degeneration and estimated...