To test the hypothesis that the long-term antihypertensive action of furosemide is mediated by a renomedullary vasodepressor substance, we measured mean arterial pressure (MAP) by radiotelemetry in Dahl-S rats with either intact or bromoethylamine-induced (BEA, 100 mg/kg i.p.) lesion of the renal papilla and medulla. Seven days of recovery after BEA administration, the rats diet was changed fro...

• The concept that the kidney may possess antihypertensive endocrine activity in various forms of experimental hypertension" has stimulated investigations into the presence and localization of renal antihypertensive substances. Although vasodepressor substances have been found in extracts of whole kidney and kidney cortex,little evidence is available to suggest a physiological role in blood pre...

Lee, Sunghou, Zheng Wu, Kathryn Sandberg, S-E. Yoo, and Christine Maric. Posttranscriptional mechanisms contribute to osmotic regulation of ANG type 1 receptors in cultured rat renomedullary interstitial cells. Am J Physiol Regul Integr Comp Physiol 290: R44–R49, 2006. First published August 11, 2005; doi:10.1152/ajpregu.00476.2005.—Previously, we showed that ANG II receptors in cultured rat re...

Renomedullary interstitial cell tumor (RMICT) is a commonly incidentally found benign tumor at autopsy. However, RMICT is rarely recognized in routine surgical pathological specimens. Renal angiomyolipoma (AML) is also an uncommon entity of renal parenchymal tumor. To the best of our knowledge, there were only three reported cases with synchronous RMICT and AML in the English literatures. Herei...