Background The heart has been demonstrated not only to be a pumping organ but also an endocrine organ secreting atrial natriuretic peptide (ANP). We hypothesized that myocardial ischemia may affect ANP secretion and that reperfusion therapy for acute myocardial infarction can preserve endocrine function of the heart. Methods and Results Twenty patients with acute right ventricular infarction we...

introduction : intestinal ischemia and reperfusion (i-i/r) is an insult associated with acute respiratory distress syndrome (ards). herein we evaluate the dose-response effect of low-level laser therapy (lllt) on lung inflammation induced by i-i/r. methods : mice were subjected to mesenteric artery occlusion (45 min) and killed after clamp release and intestinal reperfusion (2h). increasing dos...

I N 1979, DUCKERT reviewed the completed trials of intravenous (IV) thrombolytic therapy in acute myocardial infarction (MI) for this journal.’ Duckert stated in his review, “It is fair to conclude that today the value of thrombolytic treatment of acute MI has not been established.” Since this review, dramatic advances have been made in the understanding of pathogenesis of MI, knowledge of thro...

Reperfusion after acute ST-segment elevation myocardial infarction (AMI) remains the cornerstone of the initial therapy. Although reperfusion can be accomplished with either primary angioplasty or fibrinolytic therapy, clinical trial data reveal improved outcome with primary angioplasty. Furthermore, primary angioplasty with coronary stenting results in less repeat revascularization than balloo...

Acute myocardial infarction (MI) is a major cause of death and disability worldwide. In patients with MI, the treatment of choice for reducing acute myocardial ischemic injury and limiting MI size is timely and effective myocardial reperfusion using either thombolytic therapy or primary percutaneous coronary intervention (PPCI). However, the process of reperfusion can itself induce cardiomyocyt...

De Winter syndrome is a rare electrocardiographic (ECG) pattern that makes the diagnosis of ST-segment elevation myocardial infarction (STEMI) very challenging. Our case indicates early identification and such ECGs timely reperfusion therapy de as an STEMI equivalent are required to improve prognosis patients.

Early, complete, and sustained myocardial reperfusion is the principal goal of thrombolytic therapy. Unfortunately, the majority of patients treated today experience substantial delay before the initiation of thrombolytic therapy and, once treated, demonstrate suboptimal results of coronary thrombolysis. This is attributable, in part, to the underlying thrombus, which is platelet rich and resis...

BACKGROUND ST Segment Elevation Acute myocardial infarction (STEMI) preferred treatment is culprit artery reperfusion with primary percutaneous coronary intervention (PPCI). We ought to analyze the benefit of early reperfusion vs. optimal medical therapy in STEMI before and after the set-up of a regional STEMI network that prioritizes PPCI. METHODS Between January 2002 and December 2013, 1268...

Aim: Acute myocardial infarction is a major cause of morbidity and mortality worldwide. Although thrombolytic therapy primary percutaneous coronary intervention are the therapeutic approaches to reduce ischemic injury limit infarct size by providing reperfusion, process can itself induce cardiomyocyte death known as reperfusion injury. In addition effects on immunsuppression for organ transplan...

Reperfusion therapy in ST-segment elevation myocardial infarction (STEMI) is the most important component of treatment, as it strongly influences short- and long-term patient outcome. The main objective of healthcare providers should be to achieve at least 75% of reperfusion therapy applied to patients suffering from STEMI in a timely manner, and preferably within the first 3 h after onset of s...