-It is widely accepted that the early phase of primary hypertension is characterized by elevated cardiac output, whereas in later stages the increased blood pressure is due to increased peripheral resistance. To study long-term effects of increased blood flow on peripheral resistance, structural adaptation of microvascular networks in response to changes in blood flow was simulated using a prev...

At cardiac catheterization, the effect of isoproterenol on coronary blood flow was compared in six patients with normal coronary arteries and normal left ventricular function, and eight patients with angiographically defined coronary lesions. Coronary blood flow was measured by selective coronary artery injection of xenon-133 and external monitoring of disappearance curves with a dual probe, di...

Resistance to blood flow through peripheral vascular beds strongly influences cardiovascular function and transport to tissue. For a given vascular architecture, flow resistance is determined by the rheological behavior of blood flowing through microvessels. A new approach for calculating the contribution of blood rheology to microvascular flow resistance is presented. Morphology (diameter and ...

Despite the small number of leukocytes relative to erythrocytes in the circulation, leukocytes contribute significantly to organ blood flow resistance. The present study was designed to investigate whether interactions between leukocytes and erythrocytes affect the pressure-flow relationship in a hemodynamically isolated rat gracilis muscle. At constant arterial flow rate, arterial pressure was...

Low-load blood flow restricted (BFR) resistance exercise has been suggested to be as effective as moderate and high-load resistance training for increasing muscle size and strength. The purpose of the study was to evaluate the effects of 6 weeks of HL or low-load BFR resistance training on neuromuscular function, strength, and hypertrophy of the knee extensors. Eighteen participants aged 18-22 ...

BACKGROUND The aim of this study was to develop a mathematical model of blood flow in the systemic circulation to emulate the change in hemodynamics by acupuncture therapy to elucidate the mechanism of the therapy. For this purpose, as a first step, a simple model of arterial blood flow was presented to reproduce previously reported change in the blood flow volume by the acupuncture needle stim...

Introduction: Inflammatory joint diseases are common in elderly, and regulation of joint blood flow (JBF) is important in these conditions. The aim of this study was to investigate the response of inflamed joint blood vessels to angiotensin (Ang ), a vasoconstrictor factor which has been shown to be produced in inflamed joints locally. Identification of Ang receptor subtypes in joint blood ve...

a strategy employing moderate hypothermia for the replacement of the aortic arch is proposed to avoid the complications of profound hypothermic circulatory arrest. two patients underwent the complete replacement of the aortic arch using three pumps - for the brain, thoracoabdominal aorta, and heart, respectively. there were no complications and the patients were extubated uneventfully. the meth...

purpose : to evaluate orbital blood flow velocities and optic nerve diameter with doppler and gray-scale sonography in patients with acute unilateral optic neuritis (on) methods : orbital doppler and gray-scale sonography was performed in 46 eyes of 23 patients aged 19-47 with acute unilateral on. on was diagnosed by an ophthalmologist on the basis of clinical presentation, presence of decrease...

Endothelium-derived relaxing factor has been shown to regulate renal blood flow, and inhibition of its synthesis increases blood pressure and renal vascular resistance and decreases renal blood flow. Using the substrate antagonist NW-nitro-L-arginine methyl ester (L-NAME), we tested whether renal vasoconstriction induced by endothelium-derived relaxing factor synthesis inhibition could be media...