T-cell exhaustion is a progressive loss of effector function and memory potential due to persistent antigen exposure, which occurs in chronic viral infections and cancer. Here we investigate the relation between gene expression and chromatin accessibility in CD8+ tumor-infiltrating lymphocytes (TILs) that recognize a model tumor antigen and have features of both activation and functional exhaus...

At present there are no applications which include accessibility revisions for Massive Open Online Courses (MOOCs), neither in the context of MOOCs provider institutions nor from the point of view of any Open Educational Resource (OER) initiative. In this paper an approximation to this problem is presented, in the form of a specific web portal which will offer the possibility for any user to fr...

We argue that while work to optimize the accessibility of the World Wide Web through the publication and dissemination of a range of guidelines is of great importance, there is also the need for a more holistic approach to maximizing the role of the Web in enabling disabled people to access information, services and experiences. The persistently disappointingly low levels of usability of Web co...

The most exciting challenge for CRIS is to create a service for research information which should be wide-spread, distributed and actual like Google, but at the same time structured, trusted, with a complex search and navigation similar to today’s CRIS application. The core technology for such a "new" CRIS is the semantic web technology to integrate database contents with HTML/XML web pages for...

Conventional thought from the Semantic Web community equates the use of ontologies with the representation of the meaning of content. Here, e skew this viewpoint by describing our ontology, Web Authoring for Accessibility (WAfA), which investigates the way ontologies can describe he semantic structure of documents. By understanding the way heterogeneous XHTML (Extensible Hypertext Mark-up Langu...

Learners learn differently. Research shows that learners learn best when the learning experience is personalized to individual needs. Open Education Resource (OER) platforms potentially provide an ideal learning environment to meet the diverse needs of learners, including learners with disabilities. Unfortunately accessibility was not a consideration when OER were initially designed or develope...

This paper outlines the evolution of World Wide Web protocols. The paper reviews the original protocols developed for the Web, in addressing, transport and data formats. A review of developments of the protocols is given, including developments of web data formats (HTML 4.0, cascading stylesheets and XML), transport (HTTP/1.1 and HTTP/NG) and addressing (URLs). The paper describes how the web i...

BACKGROUND Recently, a global commitment has been made to expand access to antiretrovirals (ARVs) in the developing world. However, in many resource-constrained countries the number of individuals infected with HIV in need of treatment will far exceed the supply of ARVs, and only a limited number of health-care facilities (HCFs) will be available for ARV distribution. Deciding how to allocate t...

Eno powder (GlaxoSmithKline), an antacid preparation readily available over the counter, was used instead of a CO(2) generator for the growth of 15 strains of Neisseria gonorrhoeae obtained from men with urethritis. Due to its easy accessibility and low cost, Eno powder can be useful in developing countries for transporting clinical specimens from resource-poor peripheral labs to reference labo...