Anaphylaxis is an acute, severe systemic allergic reaction that can be potentially fatal. It often transition to refractory hemodynamic instability (new onset myocardial dysfunction/ left ventricular dysfunction/LVD). Stress-related cardiomyopathy (SRC) now emerging as a significant contributor of dysfunction and has multifactorial etiologies, including the excessive catecholamine released in i...

AIMS Sporadic inclusion body myositis (sIBM) is the most common late onset muscle disease causing progressive weakness. In light of the lack of effective treatment, we investigated potential causes underlying muscle wasting. We hypothesized that accumulation of mitochondrial respiratory deficiency in muscle fibres may lead to fibre atrophy and degeneration, contributing to muscle mass reduction...

conclusions despite the adverse effects of inhalational halogenated anesthetics (especially halothane) on hepatic patients when necessary. the effects on all systems must be considered and the necessary preparations must be provided. these drugs are still used, if necessary, due to the presence of positive effects and advantages mentioned in other studies as well as the adverse effects of other...

Background:Multisystem inflammatory syndrome in children (MIS-C) is a rare temporally related to severe acute respiratory coronavirus 2 (SARS-CoV-2). MIS-C shares similarities with Kawasaki disease, but left ventricular dysfunction more common MIS-C.

background and aim: some risk factors for obstructive sleep apnea (osa) such as upper respiratory airways abnormalities and obesity overlap with the risk factors for eustachian tube dysfunction (etd). in this study, we investigated the prevalence of etd in a population of patients with osa. methods: tubal dysfunction was determined by tympanometry and inflation-deflation test in 36 patients dia...

Assessing mitochondrial dysfunction requires definition of the dysfunction to be investigated. Usually, it is the ability of the mitochondria to make ATP appropriately in response to energy demands. Where other functions are of interest, tailored solutions are required. Dysfunction can be assessed in isolated mitochondria, in cells or in vivo, with different balances between precise experimenta...

background: pregnancy has a huge impact on the thyroid function in both healthy women and those that have thyroid dysfunction. the prevalence of thyroid dysfunction in pregnant women is relatively high. objective: the objective of this review was to increase awareness and to provide a review on adverse effect of thyroid dysfunction including hyperthyroidism, hypothyroidism and thyroid autoimmun...

Respiratory muscle dysfunction in chronic obstructive pulmonary disease (COPD) Dysfunction of the respiratory muscles, especially the diaphragm, is known to occur in patients with severe chronic obstructive pulmonary disease (COPD). Weakness of the diaphragm is part of a generalised process involving all (respiratory and peripheral) skeletal muscles. Causative factors for respiratory muscle dys...

Background: Increased homocysteine serum levels (HHcy) induce Endothelium Dysfunction (ED), responsible of the activation some proinflammatory agents (“cytokine storm”), imbalance between vasodilation and vasoconstriction with vasoconstrictive prevalence, increased oxidative stress hyper-coagulability. Methods: All these events can worsen course COVID-19 in HHcy- patients, favoring evolution to...