For detection of respiratory syncytial virus (RSV), the BD Directigen RSV rapid antigen assay was compared to Cepheid's real-time reverse transcriptase PCR RSV analyte-specific reagents. The Directigen RSV assay resulted in a 23% false-negative rate, using PCR and chart review as the gold standard, indicating that rapid RSV PCR results would be advantageous.

Introduction: Respiratory syncytial virus (RSV) is one of major causes of viral respiratory tract disease in young children and infants. We aimed to study the frequency of respiratory syncytial virus and its subtypes in pneumonia and bronchopneumonia in pediatric patients less than two years old tested by nested polymerase chain reaction with the evaluation of routinely used methods of diagnosi...

Virus-specific cytotoxic T lymphocytes (CTL) play a major role in the clearance of respiratory syncytial virus (RSV) infection. We have generated cytotoxic T-cell clones (TCC) from two infants who had just recovered from severe RSV infection. These TCC were functionally characterized and used to identify HLA class I (B57 and C12)-restricted CTL epitopes of RSV.

Respiratory syncytial virus (RSV) infection is a major cause of serious lower respiratory disease in infancy and early childhood. The unique pathogenesis of lower respiratory illness due to RSV offers some intriguing clues to the role of the human immune system in both protection against and development of respiratory illness. More than any other virus, rapid diagnostic techniques have been esp...

To evaluate the effects of multi-walled carbon nanotubes (MWCNT) on a host immune system, we assayed them using murine model respiratory syncytial virus (RSV) infection. MWCNT suspended in solution were intranasally administered to mice days 1, 3, and 5 before RSV On day post-infection, levels representative inflammatory markers (interferon-γ, chemokines CCL3 CCL5) bronchoalveolar lavage fluid ...

Respiratory syncytial virus (RSV) infections are associated with thrombocytopenia. The underlying mechanism of thrombocytopenia in this setting is unknown. Herein, we report a case of RSV-related thrombocytopenia associated with transient cytogenetic abnormalities that occurred following umbilical cord blood transplantation.

Abstract Respiratory syncytial virus (RSV) infection is a common cause of hospitalisation in infants and the elderly. Palivizumab prophylaxis only approved treatment modality but costly offered to select vulnerable populations. Here, we investigated gene delivery approaches via recombinant adeno-associated (rAAV2/8) simian immunodeficiency (rSIV.F/HN) vectors achieve sustained vivo production p...

A number of methods may be employed to prevent the spread of respiratory syncytial virus (RSV), including simple hand washing, screening of visitors to neonatal ICUs, and appropriate isolation and cohorting of infected infants. These standards of care must also be transferred to the home. Treatments such as acetaminophen, bronchodilators, and the antiviral agent, ribavirin, are available to tre...

Since the introduction of non-pharmacological interventions to control COVID-19, respiratory syncytial virus (RSV) activity in Europe has been limited. Surveillance data for 17 countries showed delayed RSV epidemics France (? 12 w) and Iceland 4 during 2020/21 season. cases (predominantly small children) were older compared with previous seasons. We hypothesise that future epidemic(s) could sta...