Mex3c regulates insulin-like growth factor 1 (IGF1) expression and promotes postnatal growth Y. Jiao, C. E. Bishop, and B. Lu 1404–1413 Mex3c is highly expressed in the testis, brain, and developing bone. Mex3c mutation causes postnatal growth retardation and background-dependent perinatal lethality, possibly through impairing the translation of insulin-like growth factor 1 mRNA in bone-forming...

INTRODUCTION We identified a female patient with mental retardation and sensory hyperarousal. She has a de novo paracentric inversion of one X chromosome with completely skewed inactivation of the normal X chromosome. OBJECTIVE We aimed to identify whether a single gene or gene region caused her cognitive and behavioural impairment and that of others. RESULTS Fluorescent in situ hybridisati...

Using the calculation of coefficients multiple linear regression two-dimensional correlation, we studied mutual influences (functional connectivity) between amplitudes EEG rhythms in people with mental retardation. Multiple equations were geometrically interpreted using polycyclic multigraphs. As a result studies and calculations, it was found that retardation, number correlation is determined ...

To realize cloud computing (CC), virtualization technology has been accepted as an infrastructure of Electronic Patient Records (EPR). However, it has not been sufficiently done so far to evaluate the usability of Pen-Tablet Systems (PTS) as an input device of EPR with CC environments. From our preliminary studies, we confirmed that response time retardation, which virtualization technology inh...

Insulin promotes both metabolism and growth. However, it is unclear whether insulin-dependent growth is merely a result of its metabolic actions. Targeted ablation of insulin receptor (Insr) has not clarified this issue, because of early postnatal lethality. To examine this question, we generated mice with variable cellular mosaicism for null Insr alleles. Insr ablation in approximately 80% of ...

This article studies the retardation effect in plasticity-induced fatigue crack growth rate for a low-medium strength steel, due to appearance of microdeflections path. To this end, finite element method was used model with its kinked tip under several stress intensity factor (SIF) ranges. The results allowed calculation (after small number cycles) propagation multiaxial and uniaxial configurat...

We analyze the scaling law for the polymer-induced retardation a nanoparticle experiences as it moves through a semi-dilute polymer solution. The translational friction is calculated from a modified Stokes flow using a local viscosity near the nanosphere. The results rationalize a general retardation factor, R = exp(Kac) [T. Odijk, Biophys. J. 79 (2000) 2314], revealing scaling exponents μ = 0....

BACKGROUND We report autism in 3 out of 53 children with cystic or hyperechogenic kidneys and heterozygous 17q12 region deletion encompassing hepatocyte nuclear factor-1beta (HNF1B). RESULTS They presented mental retardation, social interaction impairments, verbal and non-verbal communication deficits and stereotyped behaviours. Deletion size and location of breakpoints were similar to those ...