Reticuloendothelial system (RES) phagocytosis has been quantitated after intravenous injection of two different sets of particles by determining the clearance rate of subsequently injected identical or nonidentical particles. Injection of carbon produced a biphasic RES paralysis consisting of an early transient phase followed by a delayed sustained phase. The two phases were separated by a dist...

1. As in man, the plasma iron concentration in rats exhibits a circadian variation, with an early morning peak and an evening trough. 2. The release into the plasma of iron liberated from haemoglobin within the reticuloendothelial cells of the liver and spleen was studied by injecting heat-damaged erythrocytes containing 59Fe-labelled haemoglobin. 3. The percentage of 59Fe released was lower in...

Intravenous injections of endotoxin or infusions of thrombin in the rabbit initiate intravascular coagulation but do not usually result in massive deposition of fibrin. It has been proposed that the reticuloendothelial system may function efficiently in the removal of circulating fibrin; its blockade permits reproduction of all of the features of the generalized Shwartzman reaction by infusions...

By EVELYN GAYNOR AND THEODORE H. SPAET T HE SITE OF antihemophihic globulin ( Factor VIII ) synthesis is unknown. Since implication of the reticuloendothelial system ( RES ) has been suggested by several investigators,1’4 and others5’#{176} have suspected a splenic role, the effects of RES blockade on plasma levels of Factor VIII have been studied. Methyl palmitate induces selective depression ...