Objective: To review the current knowledge of CAD/CAM in dentistry and its development in the mentioned field. Sources: An electronic search was conducted across Ovid Medline, complemented by manual search across individual databases, such as Cochrane, Medline and ISI Web of Science databases and Google Scholar for literature analysis on the mentioned topic. The studies were reviewed thoroughly...

Introduction A recent systematic review on the use of incentives to promote questionnaire return in clinical trials suggest they are effective [1], but not all studies have sufficient funds to use them. Promising an incentive once data are returned can reduce the cost burden of this approach, with possible further cost-savings if the offer were restricted to reminder letters only. This study ai...

The coming years are anticipated to be instrumental years for a fast evolution of genome and systems modelling science and its impact in the field of evolution, development, aging and disease. The section editors, editorial board, publisher and myself look forward to working with the scientific community to publish high quality papers that address contemporary questions. In addition to reviews,...

For most training programs, the development of research endeavors among trainees is an ongoing challenge. In this article, we review various considerations when attempting to undertake research activities within an internal medicine residency training program, including availability of institutional resources (eg, dedicated research time for trainees and faculty, available faculty mentors, acce...

INTRODUCTION The unique anatomy of the hip is challenging, and has slowed the progress of hip arthroscopy. The aim of this review is to provide an updated synthesis of existing clinical evidence on hip arthroscopy. SOURCES OF DATA A systematic computerized literature search was conducted by two independent reviewers using an iterative manipulation process of the keywords used singularly or in...

BACKGROUND Randomized Controlled Trials (RCTs) represent the most valuable study design to evaluate the effectiveness of therapeutic interventions. However, flaws in design, conduct, analysis, and reporting of RCTs can cause the effect of an intervention to be under- or overestimated. These biased RCTs may be included in literature reviews. To make the assessment of Risk of Bias (RoB) consisten...

BACKGROUND Despite the growing availability of clinical practice guidelines since the early 1990's, little is known about how guideline development and dissemination may have changed over time in Canada. This study compares Canadian guideline development, dissemination, and evaluation in two six year periods from 1994-1999 and 2000-2005. METHODS Survey of guideline developers who submitted th...