High-dose methotrexate (MTX) has been extensively used for treatment of acute lymphoblastic leukemia (ALL). To determine the optimal dose of MTX in childhood relapsed ALL, the ALL Relapse Berlin-Frankfurt-Münster (ALL-REZ BFM) Study Group performed this prospective randomized study. A total of 269 children with a first early/late isolated (n = 156) or combined (n = 68) bone marrow or any isolat...

One problem with pelforming soft real-time computations on general-purpose operating systems is that these OSs may spend signiJicant amounts of time in the kernel instead ofpelforming work on behalf of the application that is nominally scheduled: the OS effectively steals time from the running application. Stolen time can be a significant obstacle -to predictable program execution on real-time ...

introduction: due to the large number of pet systems available in the market, it is not very easy to decide about the scanner of choice. conducting a research in order to compare all different pet scanners is very time consuming and expensive and practically impossible. however, such comparison may be conducted using pet simulators. in this study, the performance of 6 different pet scanners in ...

One problem with performing soft real-time computations on general-purpose operating systems is that these OSs may spend significant amounts of time in the kernel instead of performing work on behalf of the application that is nominally scheduled: the OS effectively steals time from the running application. Stolen time can be a significant obstacle to predictable program execution on real-time ...

Classical trigeminal neuralgia (TN) is a chronic pain disorder that has been described as one of the most severe pains one can suffer. The most prevalent theory of TN etiology is that the trigeminal nerve is compressed at the root entry zone (REZ) by blood vessels. However, there is significant evidence showing a lack of neurovascular compression (NVC) for many cases of classical TN. Furthermor...

Abstract The flow and heat transfers inside high-pressure (HP) compressor rotating cavities are buoyancy driven known to be extremely difficult predict. experimental data of laser-Doppler anemometry (LDA) measurements an engine representative cavity rig presented in this paper. Traverses using a two component LDA system have been carried out the shaft bore regions order map axial tangential vel...

A study of the first printed cancionero exclusively devoted to Fernán Pérez de Guzmán's poetry, a classic within fifteenth-century manuscripts, which was in Seville 1492 by Meinardo Ungut and Estanislao Polono. It is presented context Sevillian incunabula printing characterized production Polono's house. Typographical as well editorial identifications this unique copy are o...

OBJECTIVE Gamma Knife surgery (GKS) represents an alternative treatment for patients with tumor-related trigeminal neuralgia (TRTN). However, in previous studies, the primary GKS target was limited to mass lesions. The authors evaluated whether GKS could target both the tumor and the trigeminal root exit zone (REZ) in a single session while providing durable pain relief and minimizing radiation...