Methotrexate nodulosis in conditions other than rheumatoid arthritis is very rare. It has been reported in a patient with systemic lupus erythematosus and Jaccoud’s arthropathy [4], a patient with juvenile arthritis who was rheumatoid factor negative [5], and a patient with psoriatic arthritis and negative rheumatoid factor [6]. Only the patient with juvenile arthritis had pulmonary nodules. Ho...

OBJECTIVES We sought further understanding of the association between methotrexate (MTX) therapy and accelerated development of subcutaneous rheumatoid nodules. The objective was to establish expression of genes involved in the transport, metabolism, and mechanism of action of MTX within nodule tissue. We also examined for differences in gene expression between nodules from patients actively re...

Sir, Rheumatoid nodules have been reported to occur in about 20% of patients with chronic rheumatoid polyarthritis (1, 2). In the recent literature, a correlation between treatment of rheumatoid arthritis with methotrexate and the development or worsening of rheumatoid nodules has been suggested (2 ± 4). We describe here the explosive deterioration of rheumatoid nodules during the course of met...

The dramatic remissions occurring in rheumatoid arthritis during the adminis-tration of cortisone or ACTH are now familiar observations. In addition to the -volume of clinical and biochemical data already collected, there have been reports describing alterations in the pathological changes of the joint lesions with the use of these drugs. When one of our first cases to receive cortisone showed ...

Rheumatoid nodulosis is a term used to describe adult patients with rheumatoid arthritis with little or no clinical joint inflammation who have numerous subcutaneous nodules indistinguishable from those of patients with active rheumatoid arthritis. This paper reports the case of a woman with quiescent rheumatoid arthritis who developed palmar nodulosis three weeks after the strenuous activity o...

matoid disease on histologic evaluation of the pulmonary and subcutaneous lesions together. The pulmonary lesion had extensive fibrosis, as well as necrosis, and appeared to be a late relatively quiescent lesion. Angiitis was found within but not outside this lesion. Granulomatous infection was unlikely because cultures of the sputum and lung biopsy failed to grow mycobacterial or fungal organi...

We report a case of a cervical rheumatoid nodule in close relation to the hyoid bone mimicking a metastatic carcinoma. A 74-year-old female with a 15-year history of rheumatoid arthritis (RA) on treatment with methotrexate presented with tenderness of the right base of tongue. Imaging demonstrated a 1.4 cm cystic lesion at the hyoid bone. Biopsies were unsuccessful and the patient required surg...

Arthritis usually precedes the other manifestations of Whipple’s disease (WD). During this “lead time,” which may extend as long as 35 years (l), the correct diagnosis may be virtually impossible without recourse to synovial biopsy. There are scattered accounts of subcutaneous nodules with Whipple’s disease, but only a single published report of a nodule biopsy-a brief notation that “the change...