BACKGROUND Not much data are available from large, unselected, birth cohort studies on the natural course and comorbidities of rhinitis in children. OBJECTIVE To study phenotypes of rhinitis in relation to the natural course and comorbidities of allergic diseases in preschool-age and early school-age children. METHODS We analyzed data from a birth cohort of 2024 children, for whom informati...

Type I allergic diseases such as allergic rhinitis are caused by IgE-mediated humoral immune responses, while eosinophils also fulfill important roles in the etiology of IgE-mediated allergy. IL-21 regulates growth, differentiation, and function of T, B, and NK cells, while the production of IgE is also influenced by IL-21. In this study we examined whether IL-21 is capable of controlling IgE-m...

Background: Allergic disorders, including eczema, asthma, and rhinitis, have emerged as a global public health concern due to their elevated prevalence and the associated clinical morbidity. Environmental, immunologic, and genetic factors have been implicated in the pathogenesis of allergic disorders. Allergic sensitization (representing deviated immune responses) and filaggrin gene (FLG) varia...

A PCR assay was developed for the differentiation of toxigenic Pasteurella multocida subsp. multocida strains, the major etiologic agent for progressive atrophic rhinitis in pigs, from nontoxigenic strains. The PCR targeted a toxA gene encoding a 143-kDa dermonecrotic toxin that is considered to be the central etiologic factor in progressive atrophic rhinitis. toxA fragments were amplified from...

the first epidemiologic survey of childhood allergic rhinitis in iran was carried out from may 1995 until april 1996.. a questionnaire was distributed among 4584, 11-15 year-old children of both sexes, to be completed under supervision of medical students. nasal smears were collected from the cases with allergic rhinitis (n = 445, 5.8%.), and from 340 healthy children for comparison. significan...

Itching and sneezing represent two of the main bothersome symptoms, apart from nasal obstruction and rhinorrhea in allergic rhinitis. Apparently, activation of the central and peripheral nervous system plays a major role in the pathophysiology of this process. Sensory nerves of the afferent trigeminal system including myelinated Adelta-fibres and thin, non-myelinated C-fibres of the nasal mucos...

Spirulina represents a blue-green alga that is widely produced and commercialized as a dietary supplement for modulating immune functions, as well as ameliorating a variety of diseases. We have previously shown that the in vitro culture of Spirulina with human peripheral blood mononuclear cells (PBMCs) modulated the production of cytokines. In the present study, we evaluated the impact of a Spi...

Epithelial cell contribution to the natural history of childhood allergic respiratory disease remains poorly understood. Our aims were to identify epithelial pathways that are dysregulated in different phenotypes of respiratory allergy. We established gene expression signatures of nasal brushings from children with dust mite-allergic rhinitis, associated or not associated with controlled or unc...

BACKGROUND Allergic rhinitis is a disease impairing quality of life, sleep, and work. A new classification for allergic rhinitis, Allergic Rhinitis and its Impact on Asthma (ARIA), has recently been proposed. OBJECTIVE To study the effect of allergic rhinitis using ARIA definitions to determine severity and duration. METHODS A total of 3052 patients consulting general practitioners for alle...

allergic rhinitis is a very common disorder that affects children. to determine the national prevalence of allergic rhinitis symptoms in iranian children, we conducted a systematic review and meta-analysis. we conducted a literature search by using the google scholar from 1992 until 2012. the search terms were included: allergic rhinitis, isaac and iran. all the selected studies on children wer...