The retinoic acid-induced protein I (Rig-I/Ddx58), (RIG-I) initiates a signaling cascade that induces innate immune defences which is associated with the production of type I interferons (IFNs) and inflammatory cytokines to establish an antiviral state. Aberrant RIG-I signaling leads to inflammation, autoimmune diseases and cancer. However, the role of RIG-I in hepatocellular carcinoma (HCC) is...

DESCRIPTIONS of diseases and methods for their treatment can be found in the earliest available texts of the inhabitants of the Indo-gangetic plain. The oldest, the Rig-Veda, deals with non-traumatic diseases treated mainly by magical rites (Pal and Chakravorty), the later Atharva-Veda concerns itself largely with medical matters though treatment methods are still more magical than rational. Th...

Rat insulinoma gene (rig) was first isolated from a rat insulinoma cDNA library (1). Homologues of rig were also isolated from human (2), hamster (2), mouse (3), chicken (3) and Xenopus laevis (3) cDNA libraries. The amino acid sequences of isolated rig in the mammals and bird were completely conserved (100%). Using immunological methods, Kitagawa etal. (4) demonstrated that rig is in fact enco...

Veda Systems Incorporated has recently completed the development of a completely open architecture, UNIX-based software environment for standard telemetry and more generic data acquisition applications. The new software environment operates on many state-ofthe-art high-end workstations and provides a workstation independent, multiuse platform for front-end system configuration, database managem...

Vitamin A can significantly decrease measles-associated morbidity and mortality. Vitamin A can inhibit the replication of measles virus (MeV) in vitro through an RARα- and type I interferon (IFN)-dependent mechanism. Retinoid-induced gene I (RIG-I) expression is induced by retinoids, activated by MeV RNA and is important for IFN signaling. We hypothesized that RIG-I is central to retinoid-media...

conclusions our results showed that only 17% of the measured points in the oil drilling rig floor were in safe area; 39% were in caution area and 44% were in danger area. in the camp facilities area, 51% of the points were in safe area, 38% were in caution area and 11% in danger area. the main sources of noise exposure in the rig floor area were power generators. materials and methods this was ...

Protein ubiquitination plays an essential role in the regulation of retinoic acid-inducible gene I (RIG-I) activation and the antiviral immune response. However, the function of the opposite process of deubiquitination in RIG-I activation remains elusive. In this study, we have identified the deubiquitinating enzyme ubiquitin-specific protease 4 (USP4) as a new regulator for RIG-I activation th...

The caspase recruitment domain (CARD) of intracellular adaptors and sensors plays a critical role in the assembly of signaling complexes involved in innate host defense against pathogens and in the regulation of inflammatory responses. The cytosolic receptor retinoic acid-inducible gene-I (RIG-I) recognizes viral RNA in a 5'-triphosphate-dependent manner and initiates an antiviral signaling cas...

Exogenous nucleic acids induce an innate immune response in mammalian host cells through activation of the retinoic acid-inducible gene I (RIG-I). We evaluated RIG-I protein for RNA binding and ATPase stimulation with RNA ligands to investigate the correlation with the extent of immune response through RIG-I activation in cells. RIG-I protein favored blunt-ended, double-stranded RNA (dsRNA) lig...

Economic comparison of single-rig and twin-rig trawl for nephrops Economic comparison of single-rig and twin-rig trawl for nephrops