We assessed cerebrospinal fluid (CSF) levels of tau and other biomarkers of neurodegenerative disease. CSF tau levels vary widely in reports of frontotemporal dementia (FTD). CSF samples were assayed for tau, amyloid beta1-42 (A1-42), and the isoprostane 8,12-iso-iPF2a-VI (iP) prospectively in 64 patients with FTD, retrospectively in 26 autopsied cases with FTD or Alzheimer's disease (AD), and ...

The recent structural elucidation of about one dozen channels (in which we include transporters) has provided further evidence that these membrane proteins typically undergo large movements during their function. However, it is still not well understood how these proteins achieve the necessary trade-off between stability and mobility. To identify specific structural properties of channels, we c...

BACKGROUND We aimed to investigate the influence of oligomeric forms of β-amyloid (Aβ) and the influence of the duration of exposure on the development of tau phosphorylation. METHODS Aβ oligomers were injected intracranially either acutely into 5-month-old rTg4510 mice and tissue was collected 3 days later, or chronically into 3-month-old mice and tissue was collected 2 months later. Several...

we first characterize $tau$-complemented modules with relative (pre)-covers. we also introduce an extending module relative to $tau$-pure submodules on a hereditary torsion theory $tau$ and give its relationship with $tau$-complemented modules.

In this paper, we introduce the notions of expansion of ideals in $MV$-algebras, $ (tau,sigma)- $primary, $ (tau,sigma)$-obstinate  and $ (tau,sigma)$-Boolean  in $ MV- $algebras. We investigate the relations of them. For example, we show that every $ (tau,sigma)$-obstinate ideal of an $ MV-$ algebra is $ (tau,sigma)$-primary  and $ (tau,sigma)$-Boolean. In particular, we define an expansion $ ...

The mSUGRA model predicts the polarization of the tau coming from the stau to bino decay in the co-annihilation region to be +1. This can be exploited to extract this soft tau signal at LHC and also to measure the tiny mass differences between the stau and the bino LSP. Moreover this strategy will be applicable for a wider class of bino LSP models, where the lighter stau has a right component a...

BACKGROUND Cerebrospinal fluid (CSF) biomarkers and quantitative EEG show particular patterns of change in Alzheimer's disease (AD) and reflect neuropathologic processes and cerebral function, respectively. The changes precede cognitive decline and should be visible already in preclinical stages. We therefore aimed to investigate their relationship in cognitively healthy individuals. METHOD T...

In this paper, we study the asymptotic stability and hair-trigger effect for Cauchy problem of following parabolic-parabolic Keller-Segel system with logistic term$ \begin{equation} \left\{ \begin{aligned} &u_{t} = \Delta u-\chi \nabla\cdot\left ( u\nabla v \right )+u\left(a-b u\right)&x\in \mathbb{R}^{N},\, t>0,\\ &\tau v_{t} v+\lambda u-\mu v&x\in t>0, \end{aligned} \rig...

Reaching towards a visual object in the absence of visual referents relies on a chain of information, from the sensory signals encoding the object's image on the retina, to the motor signals driving the hand. One link in this chain is an extraretinal eye position signal (EEPS), which specifies the position of the eye in the head. EEPS must be updated in precise coordination with the eye's rapid...